TCID - Moligand™, 10mM in DMSO , Inhibitor of ubiquitin C-terminal hydrolase L3, CAS No.30675-13-9, Inhibitor of ubiquitin C-terminal hydrolase L3

CAS: 30675-13-9 Cat. No.: T423175 分子式: C₉H₂Cl₄O₂ 分子量: 283.92 EC番号: 970-953-3 PubChem CID: 2729042

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

4,5,6,7-Tetrachloroindane-1,3-dione | C9H2Cl4O2 | Maybridge1_006552 | GTPL8660 | HMS3653C11 | HMS560B18 | UCH 23;UCH23;UCH-23;UCH-L3 Inhibitor;4,5,6,7-tetrachloroindan-1,3-dione | UCH-L3 | UCH-L3 Inhibitor | 4,5,6,7-Tetrachloro indane-1,3-dione | HY-18638

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Specifications

同義語

4,5,6,7-Tetrachloroindane-1,3-dione | C9H2Cl4O2 | Maybridge1_006552 | GTPL8660 | HMS3653C11 | HMS560B18 | UCH 23;UCH23;UCH-23;UCH-L3 Inhibitor;4,5,6,7-tetrachloroindan-1,3-dione | UCH-L3 | UCH-L3 Inhibitor | 4,5,6,7-Tetrachloro indane-1,3-dione | HY-18638

仕様と純度

Moligand™, 10mM in DMSO

生化学的・生理学的メカニズム

TCID is a cell penetrant potent and specific inhibitor of UCH-L3 (Ubiquitin carboxyl-terminal hydrolase isozyme L3). TCID is used to distinguish between UCH-L1 and UCH-L3 activities in cells.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

INHIBITOR

作用メカニズム

Inhibitor of ubiquitin C-terminal hydrolase L3

名前と識別子

• パブケム・シド: 528767370
• カノニカル・スマイル: C1C(=O)C2=C(C1=O)C(=C(C(=C2Cl)Cl)Cl)Cl
• IUPAC Name: 4,5,6,7-tetrachloroindene-1,3-dione
• InChIKey: IDLAOWFFKWRNHB-UHFFFAOYSA-N
• INCHI: 1S/C9H2Cl4O2/c10-6-4-2(14)1-3(15)5(4)7(11)9(13)8(6)12/h1H2
• 異性体SMILES: C1C(=O)C2=C(C1=O)C(=C(C(=C2Cl)Cl)Cl)Cl
• PubChem CID: 2729042
• 分子量: 283.92

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • 分類 Indanes
      • Subclass Indanones

• Kingdom: Organic compounds
• Superclass: Benzenoids
• 分類: Indanes
• Subclass: Indanones
• Intermediate Tree Nodes: Not available
• Direct Parent: Indanediones
• Alternative Parents: Aryl alkyl ketones Beta-diketones Aryl chlorides Vinylogous halides Organochlorides Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: Indanedione - Aryl ketone - Aryl alkyl ketone - 1,3-diketone - Aryl chloride - Aryl halide - 1,3-dicarbonyl compound - Vinylogous halide - Ketone - Organooxygen compound - Organochloride - Organohalogen compound - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Aromatic homopolycyclic compound
• 説明: This compound belongs to the class of organic compounds known as indanediones. These are compounds containing an indane ring bearing two ketone groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

関連ターゲット（人間）

UCHL3 Tchem Ubiquitin carboxyl-terminal hydrolase isozyme L3 (2 Activities)

Discover Target: UCHL3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

UCHL1 Tchem Ubiquitin carboxyl-terminal hydrolase isozyme L1 (107 Activities)

Discover Target: UCHL1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

UCHL3 Tchem Ubiquitin carboxyl-terminal hydrolase isozyme L3 (50 Activities)

Discover Target: UCHL3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

関連ターゲット（非人間）

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

作用メカニズム

化学的性質と物理的性質

• 分子量: 283.900 g/mol
• XLogP3: 3.900
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 283.878 Da
• Monoisotopic Mass: 281.881 Da
• Topological Polar Surface Area: 34.100 Ų
• Heavy Atom Count: 15
• Formal Charge: 0
• Complexity: 289.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

参考文献

1. Shaowei Bo, Dong Zhang, Mengjie Ma, Xukai Mo, Julia Stabinska, Michael T. McMahon, Changzheng Shi, Liangping Luo.  (2023)  Acyl Hydrazides and Acyl Hydrazones as High-Performance Chemical Exchange Saturation Transfer MRI Contrast Agents.  Pharmaceuticals,  16  (5): (639).  [PMID:37242423] [10.3390/ph16050639]

2. Wang Qian, He Yuan, Lu Rui, Wang Wen-Ming, Yang Ke-Wu, Fan Hai Ming, Jin Yi, Blackburn G. Michael.  (2018)  Thermokinetic profile of NDM-1 and its inhibition by small carboxylic acids.  BIOSCIENCE REPORTS,  38  (2):   [PMID:29507059] [10.1042/BSR20180244]

3. Guiying Zhu, Chaozheng Liu, Changli Zhang, Jiangtao Shi, Changtong Mei, Mingzhu Pan, Zhipeng Liu.  (2024)  Activating the Room-Temperature Phosphorescence of Organic Dyes through the Confinement Effect of Delignified Wood.  ACS Sustainable Chemistry & Engineering,      [PMID:] [10.1021/acssuschemeng.3c07507]

4. Binhao Wang, Yu Shen, Ruonan Hao, Shuheng Pan, Ruizhi Han, Ye Ni.  (2025)  Novel Approach for Efficient Separation of Primary Amines Using Supercritical Fluid Chromatography.  CHIRALITY,  37  (1): (e70012).  [PMID:39800655] [10.1002/chir.70012]