TH 1217 - ≥98%(HPLC) , CAS No.1862212-48-3

CAS: 1862212-48-3 Cat. No.: T288726 分子式: C₂₀H₁₇BCl₂N₄O₆ 分子量: 491.09 PubChem CID: 137919863

GRADE & PURITY ≥98%(HPLC)

Synonyms

2-[4-[[5,6-Dichloro-2-methyl-4-nitro-1H-benzo[d]-imidazol-1-yl]methyl]phenyl]-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

Product description：

TH1217 (ZINC1775962367) is a potent and selective dCTPase pyrophosphatase 1 (dCTPase) inhibitor, with an IC50 of 47 nM. TH1217 enhances the cytotoxic effect of cytidine analogues in leukemia cells. TH1217 also could modulate SARS-Cov-2 interactors, so it shows activity of against COVID-19.

Specifications

同義語

2-[4-[[5,6-Dichloro-2-methyl-4-nitro-1H-benzo[d]-imidazol-1-yl]methyl]phenyl]-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione

仕様と純度

≥98%(HPLC)

生化学的・生理学的メカニズム

Potent dCTPase pyrophosphatase 1 inhibitor (IC50= 47 nM).TH 1217 is not stable in aqueous solution. It is recommended that fresh samples are prepared and used immediately.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

アクションタイプ

MODULATOR

純度

≥98%(HPLC)

名前と識別子

• パブケム・シド: 528767393
• カノニカル・スマイル: CC1=NC2=C([N+]([O-])=O)C(Cl)=C(C=C2N1CC3=CC=C([B-]45OC(C[N+](CC(O5)=O)4C)=O)C=C3)Cl
• InChIKey: HWFRCQHNILGMLL-UHFFFAOYSA-N
• PubChem CID: 137919863
• 分子量: 491.09

化学的性質と物理的性質

• 溶解度: Solvent:DMSO, Max Conc. mg/mL: 49.11, Max Conc. mM: 100