Name: TH 257 - ≥98%(HPLC) , CAS No.2244678-29-1
SKU: T287707
Availability: InStock

TH 257 - ≥98%(HPLC) , CAS No.2244678-29-1

CAS: 2244678-29-1 Cat. No.: T287707 分子式: C₂₄H₂₆N₂O₃S 分子量: 422.54 PubChem CID: 137796294

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TH 257 - ≥98%(HPLC) CAS No(2244678-29-1) by Aladdin Scientific

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注文可能

GRADE & PURITY ≥98%(HPLC)

Synonyms

N-Butyl-4-[(phenylamino)sulfonyl]-N-(phenylmethyl)benzamide

Storage

Store at 2-8°C

Shipped In

Wet ice

概要 Specifications 名前と識別子 Documentation Advanced Data Taxonomic Classification 3 D構造関連ターゲット（人間）関連ターゲット（非人間）作用メカニズム証明書（CoA、COO、BSE/TSEと分析図）化学的性質と物理的性質ソリューション計算機レビュー

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Why this grade

≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

概要

product description：

TH-257 is a potent and exquisitely selective LIM kinase (LIMK) inhibitor with IC50 of 84 nM and 39 nM for LIMK1 and LIMK2, respectively.

Specifications

同義語

N-Butyl-4-[(phenylamino)sulfonyl]-N-(phenylmethyl)benzamide

仕様と純度

≥98%(HPLC)

生化学的・生理学的メカニズム

Potent and selective allosteric LIMK 1/2 inhibitor (IC50values are 84 and 39 nM, respectively). Inhibits cofilin phosphorylationin vitro. Exhibits no significant activity against the wider kinome.

保管条件

Store at 2-8°C

入荷

Wet ice

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥98%(HPLC)

名前と識別子

パブケム・シド	504773514
パブケム・シド・ウル	https://pubchem.ncbi.nlm.nih.gov/substance/504773514
カノニカル・スマイル	CCCCN(CC1=CC=CC=C1)C(=O)C2=CC=C(C=C2)S(=O)(=O)NC3=CC=CC=C3
IUPAC Name	N-benzyl-N-butyl-4-(phenylsulfamoyl)benzamide
InChIKey	VNCIWNGCMAKKEO-UHFFFAOYSA-N
INCHI	1S/C24H26N2O3S/c1-2-3-18-26(19-20-10-6-4-7-11-20)24(27)21-14-16-23(17-15-21)30(28,29)25-22-12-8-5-9-13-22/h4-17,25H,2-3,18-19H2,1H3
異性体SMILES	CCCCN(CC1=CC=CC=C1)C(=O)C2=CC=C(C=C2)S(=O)(=O)NC3=CC=CC=C3
PubChem CID	137796294
分子量	422.54

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - 分類 Benzene and substituted derivatives
    - Subclass Benzenesulfonamides

Kingdom	Organic compounds
Superclass	Benzenoids
分類	Benzene and substituted derivatives
Subclass	Benzenesulfonamides
Intermediate Tree Nodes	Not available
Direct Parent	Benzenesulfonamides
Alternative Parents	Benzamides Benzoyl derivatives N-acyl amines Tertiary carboxylic acid amides Sulfonyls Organosulfonic acids and derivatives Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Benzenesulfonamide - Benzoic acid or derivatives - Benzamide - Benzoyl - N-acyl-amine - Tertiary carboxylic acid amide - Sulfonyl - Organosulfonic acid or derivatives - Carboxamide group - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Aromatic homomonocyclic compound
説明	This compound belongs to the class of organic compounds known as benzenesulfonamides. These are organic compounds containing a sulfonamide group that is S-linked to a benzene ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3 D構造

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レビュー

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Lot Number	Certificate Type	日付	商品
E2213111	Certificate of Analysis	Feb 07, 2025	T287707
E2213112	Certificate of Analysis	Feb 07, 2025	T287707
E2213126	Certificate of Analysis	Feb 07, 2025	T287707
E2213153	Certificate of Analysis	Feb 07, 2025	T287707
E2213154	Certificate of Analysis	Feb 07, 2025	T287707

溶解度	Solvent:DMSO, Max Conc. mg/mL: 42.25, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 42.25, Max Conc. mM: 100
分子量	422.500 g/mol
XLogP3	4.700
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	9
Exact Mass	422.166 Da
Monoisotopic Mass	422.166 Da
Topological Polar Surface Area	74.900 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	611.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1