(-)-TK216 - Moligand™,10mM in DMSO , CAS No.1903783-78-7

CAS: 1903783-78-7 Cat. No.: T655209 分子式: C₁₉H₁₅Cl₂NO₃ 分子量: 376.23 PubChem CID: 121268274

GRADE & PURITY Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

(-)-TK216 is an enantiomer of TK216 . TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor. (-)-TK216 has anti-cancer activity.

In Vitro

(-)-TK216 (compound 14; for 3 days) has an IC 50 <5 μM in SKES cells (Ewing Sarcoma cell line). (-)-TK216 has T 1/2 s of 27.7 mins, 2.8 mins, 23.1 mins and 40.8 mins for human, rat, mouse, dog liver microsomes. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

(-)-TK216 (compound 14; 5 mg/kg for iv or 25 mg/kg for po) has T 1/2 s of 0.8 hours and 3.1 hours, and AUCs of 4131 h•(ng/mL) and 13152 h•(ng/mL) for iv and po, respectively, in BALB/c mice or Sprague Dawley rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications

仕様と純度

Moligand™,10mM in DMSO

生化学的・生理学的メカニズム

(-)-TK216 is an enantiomer of TK216 ( HY-122903 ). TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor. (-)-TK216 has anti-cancer activity.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

INHIBITOR

名前と識別子

• PubChem CID: 121268274
• 分子量: 376.23