TMP195 - 10mM in DMSO , CAS No.1314891-22-9

CAS: 1314891-22-9 Cat. No.: T408048 分子式: C₂₃H₁₉F₃N₄O₃ 分子量: 456.42 PubChem CID: 67324851

GRADE & PURITY 10mM in DMSO

Synonyms

TFMO 2 | Benzamide, N-​[2-​methyl-​2-​(2-​phenyl-​4-​oxazolyl)​propyl]​-​3-​[5-​(trifluoromethyl)​-​1,​2,​4-​oxadiazol-​3-​yl]​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

TMP195 TMP195 (TFMO 2) is a selective, first-in-class, class IIa HDAC inhibitor with IC50 of 300 nM in cell-based class IIa HDAC assays.
In vitro

TMP195 has low potency in recombinant class I and IIb HDAC assays, enabling full inhibition of class IIa HDAC activity without inhibition of other HDACs. TMP195 blocks the accumulation of CCL2 protein in the supernatants of monocyte-derived macrophage differentiation cultures and significantly increases the amount of CCL1 protein secreted by the monocytes compared to vehicle (DMSO)-treated M-CSF plus GM-CSF cultures. TMP195 influences human monocyte responses to the colony-stimulating factors CSF-1 and CSF-2 in vitro.

In vivo

In vivo TMP195 treatment alters the tumour microenvironment and reduces tumour burden and pulmonary metastases by modulating macrophage phenotypes. TMP195 induces the recruitment and differentiation of highly phagocytic and stimulatory macrophages within tumours. TMP195 treatment significantly decreases proliferating tumour cells, most notably at the leading edge of the tumour. The anti-tumour macrophage phenotype induced by TMP195 treatment thus enhances the efficacy and durability of both standard chemotherapeutic regimens and checkpoint blockade immunotherapy in this mouse model of breast cancer.
Cell Data

cell lines：

Concentrations：300 nM

Incubation Time：5 days

Powder Purity:≥98%

Specifications

同義語

TFMO 2 | Benzamide, N-​[2-​methyl-​2-​(2-​phenyl-​4-​oxazolyl)​propyl]​-​3-​[5-​(trifluoromethyl)​-​1,​2,​4-​oxadiazol-​3-​yl]​-

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

TMP195 (TFMO 2) is a selective, first-in-class, class IIa HDAC inhibitor with IC50 of 300 nM in cell-based class IIa HDAC assays.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

製品の性質

• ALogP: 4.525
• HBD数: 1
• 回転可能な結合: 7

名前と識別子

• 異性体SMILES: CC(C)(CNC(=O)C1=CC=CC(=C1)C2=NOC(=N2)C(F)(F)F)C3=COC(=N3)C4=CC=CC=C4
• PubChem CID: 67324851
• 分子量: 456.42

関連ターゲット（人間）

HDAC4 Tclin Histone deacetylase 4 (1 Activities)

Discover Target: HDAC4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC7 Tclin Histone deacetylase 7 (1 Activities)

Discover Target: HDAC7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC9 Tclin Histone deacetylase 9 (1 Activities)

Discover Target: HDAC9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC5 Tclin Histone deacetylase 5 (1 Activities)

Discover Target: HDAC5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

化学的性質と物理的性質

• 溶解度: Solubility (25°C) In vitro Water: 24 mg/mL (9.17 mM)
• DMSO（mg / mL） 最大溶解度: 91
• DMSO（mM） 最大溶解度: 199.3777661
• 水（mg / mL） 最大溶解度: ＜1

よくある質問

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1314891-22-9, the molecular formula is C23H19F3N4O3, and the molecular weight is 456.42 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.