TMX-4116 - 10mM in DMSO , CAS No.2766385-56-0

CAS: 2766385-56-0 Cat. No.: T655121 分子式: C₁₇H₁₉N₅O₄S 分子量: 389.43

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

TMX-4116 is a casein kinase 1α ( CK1α ) degrader. TMX-4116 shows the degradation preference for CK1α with DC 50 s less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4116 can be used for the research of multiple myeloma

In Vitro

TMX-4116 (compound 16; 1 μM; 4 h) shows a high degradation preference for CK1α in MOLT4 cells. TMX-4116 (250 nM, 4 h) induces primary target degradation of CK1α, while no downregulation of PDE6D, IKZF1, and IKZF3 in MOLT4 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: MOLT4 cells Concentration: 1 μM Incubation Time: 4 hours Result: Showed a high degradation preference for CK1α. Western Blot AnalysisCell Line: MOLT4, Jurkat, and MM.1S cells Concentration: 0 nM, 40 nM, 200 nM, 1 μM Incubation Time: 4 hours Result: Showed a high degradation preference for CK1α with the DC 50 value less than 200 nM in MOLT4, Jurkat, and MM.1S cells.

IC50& Target:CK1α

Specifications

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

TMX-4116 is a casein kinase 1α ( CK1α ) degrader. TMX-4116 shows the degradation preference for CK1α with DC 50 s less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4116 can be used for the research of multiple myeloma.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

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名前と識別子

• 分子量: 389.43