Tolimidone - Moligand™, ≥98%(HPLC) , Allosteric modulator of LYN proto-oncogene; Src family tyrosine kinase, CAS No.41964-07-2, Allosteric modulator of LYN proto-oncogene; Src family tyrosine kinase

CAS: 41964-07-2 Cat. No.: T133701 分子式: C₁₁H₁₀N₂O₂ 分子量: 202.21 EC番号: 803-991-5 PubChem CID: 39065

グレード＆純度 Moligand™, ≥98%(HPLC)

Synonyms

MU3JD8E9IS | s8321 | 5-(3-methylphenoxy)-2(1h)-pyrimidinone | HMS3749I15 | AS-16416 | SMR004704144 | GTPL9433 | 5-(m-tolyloxy)pyrimidin-2(1H)-one | NSC-314335 | TOLIMIDONE | NSC314335 | 5-(m-Tolyloxy)-2(1H)-pyrimidinone | A899682 | AC-37077 | BDBM50545405

Storage

Store at 2-8°C

Shipped In

Wet ice

仕様

同義語

MU3JD8E9IS | s8321 | 5-(3-methylphenoxy)-2(1h)-pyrimidinone | HMS3749I15 | AS-16416 | SMR004704144 | GTPL9433 | 5-(m-tolyloxy)pyrimidin-2(1H)-one | NSC-314335 | TOLIMIDONE | NSC314335 | 5-(m-Tolyloxy)-2(1H)-pyrimidinone | A899682 | AC-37077 | BDBM50545405

仕様と純度

Moligand™, ≥98%(HPLC)

生化学的・生理学的メカニズム

Selective allosteric activator of Lyn kinase (EC50= 63 nM); displays no significant activity against a range of 47 other kinases, including other Src family kinases such as Fyn, Lck and Src kinase. Reduces blood glucose levels without affectingin vivoinsu

保管条件

Store at 2-8°C

入荷

Wet ice

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

ALLOSTERIC MODULATOR

作用メカニズム

Allosteric modulator of LYN proto-oncogene; Src family tyrosine kinase

純度

≥98%(HPLC)

製品の性質

ALogP

1.4

名前と識別子

パブケム・シド

504753579

パブケム・シド・ウル

https://pubchem.ncbi.nlm.nih.gov/substance/504753579

カノニカル・スマイル

CC1=CC(=CC=C1)OC2=CNC(=O)N=C2

IUPAC Name

5-(3-methylphenoxy)-1H-pyrimidin-2-one

InChIKey

HJQILFPVRNHTIG-UHFFFAOYSA-N

INCHI

1S/C11H10N2O2/c1-8-3-2-4-9(5-8)15-10-6-12-11(14)13-7-10/h2-7H,1H3,(H,12,13,14)

異性体SMILES

CC1=CC(=CC=C1)OC2=CNC(=O)N=C2

WGKドイツ

3

代替CAS番号

41964-07-2

PubChem CID

39065

NSC番号

314335

MeSH用語

5-(3-methylphenoxy)-2(1H)-pyrimidinone;MLR-1023

分子量

202.21

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic oxygen compounds
    • 分類 Organooxygen compounds
      • Subclass Ethers

• Kingdom: Organic compounds
• Superclass: Organic oxygen compounds
• 分類: Organooxygen compounds
• Subclass: Ethers
• Intermediate Tree Nodes: Not available
• Direct Parent: Diarylethers
• Alternative Parents: Phenoxy compounds Phenol ethers Toluenes Pyrimidones Hydropyrimidines Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Diaryl ether - Phenoxy compound - Phenol ether - Toluene - Pyrimidone - Monocyclic benzene moiety - Hydropyrimidine - Benzenoid - Pyrimidine - Heteroaromatic compound - Azacycle - Organoheterocyclic compound - Organic nitrogen compound - Hydrocarbon derivative - Organonitrogen compound - Organic oxide - Organopnictogen compound - Aromatic heteromonocyclic compound
• 説明: This compound belongs to the class of organic compounds known as diarylethers. These are organic compounds containing the dialkyl ether functional group, with the formula ROR', where R and R' are aryl groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

関連ターゲット（人間）

LYN Tclin Tyrosine-protein kinase Lyn (1 Activities)

Discover Target: LYN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LYN Tclin Tyrosine-protein kinase Lyn (4251 Activities)

Discover Target: LYN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

関連ターゲット（非人間）

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cavia porcellus (23802 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

作用メカニズム

化学的性質と物理的性質

• 溶解度: Solvent:DMSO, Max Conc. mg/mL: 20.22, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 4.04, Max Conc. mM: 20
• 分子量: 202.210 g/mol
• XLogP3: 1.400
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 202.074 Da
• Monoisotopic Mass: 202.074 Da
• Topological Polar Surface Area: 50.700 Ų
• Heavy Atom Count: 15
• Formal Charge: 0
• Complexity: 310.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

よくある質問

What is the purity of this product, and how is it determined?

This product is supplied at ≥98% purity, determined by HPLC. Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at 2–8 °C. Refrigerated storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 41964-07-2, the molecular formula is C11H10N2O2, and the molecular weight is 202.21 g/mol. InChIKey HJQILFPVRNHTIG-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.