2-[(4-[4-(Pyridin-4-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-yl]phenoxy)methyl]quinoline - Moligand™, ≥99% , CAS No.898563-00-3

CAS: 898563-00-3 Cat. No.: T650352 分子式: C₂₆H₁₉F₃N₄O 分子量: 460.45

GRADE & PURITY Moligand™, ≥99%

Synonyms

TP-10

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

TP-10 is a selective PDE10A inhibitor with an IC 50 value of 0.8 nM. TP-10 shows an antioxidant activity with IC 50 s of 31.72 and 16.04 μg/ml for DPPH and CUPRAC, respectively. TP-10 can be used for the research of neuropathy

In Vitro（for reference only）

TP-10 (10 μg /mL; 24 h) affects total reactive oxygen species in human brain-derived cells (U-87 MG).

Cell Viability Assay

Cell Line: U-87 MG cells

Concentration: 10 μg/ml

Incubation Time: 24 hours

Result: Decreased the total number of ROS-positive cells and showed no toxic effects to U-87 MG cells.

In Vivo（for reference only）

TP-10 (0.1-10 mg/kg; i.h. once) shows an effect on cyclic nucleotides.

Animal Model: Male CD rats

Dosage: 0.1, 0.32, 1.0, 3.2 and 10 mg/kg

Administration: Subcutaneous injection; 0.1-10 mg/kg once

Result: Dose- and time-dependently increased the levels of both cGMP and cAMP in striatal of mice. Increased pCREB-LI level first and returned to basal levels after injected for 3 hours at a dose of 3.2 mg/kg.

Form:Solid

IC50& Target:IC50: 0.8 nM (PDE10A), 31.72 μg/mL (DPPH), 16.04 μg/mL (CUPRAC)

Specifications

同義語

TP-10

仕様と純度

Moligand™, ≥99%

生化学的・生理学的メカニズム

TP-10 is a selective PDE10A inhibitor with an IC 50 value of 0.8 nM. TP-10 shows an antioxidant activity with IC 50 s of 31.72 and 16.04 μg/ml for DPPH and CUPRAC, respectively. TP-10 can be used for the research of neuropathy.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

INHIBITOR

純度

≥99%

名前と識別子

• 分子量: 460.45

化学的性質と物理的性質

• 溶解度: DMSO : 100 mg/mL (217.18 mM; Need ultrasonic)