2,4,7-Triamino-6-phenylpteridine - Moligand™, 10mM in DMSO , Amiloride-sensitive sodium channel, ENaC blocker, CAS No.396-01-0, Amiloride-sensitive sodium channel, ENaC blocker

CAS: 396-01-0 Cat. No.: T408932 分子式: C₁₂H₁₁N₇ 分子量: 253.26 EC番号: 206-904-3 PubChem CID: 5546

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

SKF8542 | 2,4,7-Pteridinetriamine, 6-phenyl-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

Triamterene Triamterene (SKF8542) blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner with IC50 of 4.5 μM.
In vitro

Triamterene inhibits the epithelial sodium channels on principal cells in the late distal convoluted tubule and collecting tubule, which are responsible for 1-2% of total sodium reabsorption. Triamterene can achieve a modest amount of diuresis by decreasing the osmotic gradient necessary for water reabsorption from lumen to interstitium. Triamterene also has a potassium-sparing effect. Normally, the process of potassium excretion is driven by the electrochemical gradient produced by sodium reabsorption. As sodium is reabsorbed, it leaves a negative potential in the lumen, while producing a positive potential in the principal cell. This potential promotes potassium excretion through apical potassium channels. By inhibiting sodium reabsorption, triamterene also inhibits potassium excretion.

In vivo

4\'-hydroxylation of triamterene in humans appears to be mediated exclusively by CYP1A2. Inhibition or induction of CYP1A2 will change the time course of both triamterene and its active phase-II metabolite.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

同義語

SKF8542 | 2,4,7-Pteridinetriamine, 6-phenyl-

仕様と純度

Moligand™, 10mM in DMSO

生化学的・生理学的メカニズム

Triamterene (SKF8542) blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner with IC50 of 4.5 μM.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

BLOCKER, CHANNEL BLOCKER

作用メカニズム

Amiloride-sensitive sodium channel, ENaC blocker

製品の性質

ALogP

1

名前と識別子

異性体SMILES

C1=CC=C(C=C1)C2=NC3=C(N=C(N=C3N=C2N)N)N

PubChem CID

5546

分子量

253.26

関連ターゲット（人間）

SCNN1A Tclin Amiloride-sensitive sodium channel subunit alpha (0 Activities)

Discover Target: SCNN1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCNN1G Tclin Amiloride-sensitive sodium channel subunit gamma (0 Activities)

Discover Target: SCNN1G

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCNN1B Tclin Amiloride-sensitive sodium channel subunit beta (0 Activities)

Discover Target: SCNN1B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

化学的性質と物理的性質

• 融点（°C）: >300