≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
TTT-28 is a synthesized thiazole-valine peptidomimetic, a novel selective inhibitor of ABCB1 (P-gp/MDR1) with high efficacy and low toxicity, which reverses the ATP-binding cassette sub-family B member 1 ( ABCB1 )-mediated multidrug resistance (MDR) by selectively blocking the efflux function of ABCB1.
In Vitro
TTT-28 (0-100 μM; 72 hours) reverses ABCB1-mediated MDR in drug selected SW620/Ad300 cells and transfected HEK293/ABCB1 cells; the IC 50 s of TTT-28 in CCD-18Co, SW620 and SW620/Ad300 cells are 213.4±11.0 μM, 89.4±3.9 μM and 92.0±5.0 μM, respectively. TTT-28 (10 μM; 2 hours) raises the ABCB1-mediated MDR and increased the accumulation of [ 3 H]-paclitaxel in ABCB1 overexpressing cells. TTT-28 (10 μM; 0-72 hours) does not interfer with the expression level and localization of ABCB1, it results from blocking the efflux function of ABCB1. TTT-28 (0-40 μM; 2 hours) interacts at the drug-substrate-binding site and actives the ATPase activity of ABCB1 in a concentration-dependent fashion. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: SW620 cells, SW620/Ad300 cells Concentration: 0.1 μM, 1 μM, 10 μM, 100 μM Incubation Time: 72 hours Result: Decreased the resistance fold of ABCB1 substrates (Paclitaxel, Doxorubicin, Vincristine) in SW620/Ad300 cells compared to SW620 cells.
In Vivo
TTT-28 (deliver orally; 30 mg/kg; every 3 rd day; 18 days) potentiates the anticancer activity of paclitaxel due to its inhibitory effect on the efflux function of ABCB1, it enhances the inhibitory effect of paclitaxel on the growth of SW620/Ad300 tumor and promoted apoptosis . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 5-10 week Male athymic NCR (nu/nu) nude mice ABCB1 overexpressing tumor xenograft model with SW620/Ad300 cells Dosage: 30 mg/kg Administration: Deliver orally; every 3rd day; 18 days Result: Lead to higher intratumoral accumulation of paclitaxel in tumors.
Form:Solid
Comprehensive hazard, handling, storage, and regulatory compliance document.
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View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| 分類 | Benzene and substituted derivatives |
| Subclass | Benzophenones |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Benzophenones |
| Alternative Parents | Aromatic anilides Aryl-phenylketones Diphenylmethanes Benzamides Phenoxy compounds Methoxybenzenes 2-heteroaryl carboxamides Benzoyl derivatives Anisoles Thiazolecarboxamides 2,4-disubstituted thiazoles Alkyl aryl ethers Heteroaromatic compounds Vinylogous amides Secondary carboxylic acid amides Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteromonocyclic compounds |
| Substituents | Benzophenone - Aromatic anilide - Diphenylmethane - Aryl-phenylketone - Benzoic acid or derivatives - Benzamide - 2-heteroaryl carboxamide - Benzoyl - Phenol ether - Thiazolecarboxamide - Thiazolecarboxylic acid or derivatives - Aryl ketone - Anisole - Methoxybenzene - Phenoxy compound - 2,4-disubstituted 1,3-thiazole - Alkyl aryl ether - Thiazole - Heteroaromatic compound - Azole - Vinylogous amide - Secondary carboxylic acid amide - Carboxamide group - Ketone - Carboxylic acid derivative - Organoheterocyclic compound - Azacycle - Ether - Organic oxygen compound - Organooxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Organonitrogen compound - Organic oxide - Aromatic heteromonocyclic compound |
| 説明 | This compound belongs to the class of organic compounds known as benzophenones. These are organic compounds containing a ketone attached to two phenyl groups. |
| External Descriptors | Not available |
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| 溶解度 | DMSO : 250 mg/mL (435.80 mM; Need ultrasonic) |
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