UAMC-3203 - 10mM in DMSO , CAS No.2271358-64-4

CAS: 2271358-64-4 Cat. No.: U408498 分子式: C₂₅H₃₇N₅O₂S 分子量: 471.66 PubChem CID: 137701965

グレード＆純度 10mM in DMSO

Synonyms

Benzenesulfonamide, 4-​(cyclohexylamino)​-​3-​[(phenylmethyl)​amino]​-​N-​[2-​(1-​piperazinyl)​ethyl]​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

UAMC-3203 UAMC-3203 is an improved ferroptosis inhibitor with an IC50 value of 10 nM in IMR-32 neuroblastoma cells.
In vitro

UAMC-3203 has an impressive t1/2 when incubated with both human and rat microsomes (t1/2 = 20.5 h and t1/2 = 16.5 h respectively) but is found to be relatively less stable when incubated with murine microsomes (t1/2 = 3.46 h).

In vivo

UAMC-3203 significantly lowers the plasma levels of lactate dehydrogenase (LDH) in mice. It is rapidly removed from the bloodstream and redistributed into various tissues, as can be expected for lipophilic basic compounds. Significant concentrations of UAMC-3203 are found in all analyzed tissues (liver, kidney, and lungs).
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥98%

仕様

同義語

Benzenesulfonamide, 4-​(cyclohexylamino)​-​3-​[(phenylmethyl)​amino]​-​N-​[2-​(1-​piperazinyl)​ethyl]​-

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

UAMC-3203 is an improved ferroptosis inhibitor with an IC50 value of 10 nM in IMR-32 neuroblastoma cells.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

製品の性質

ALogP

3.36

HBD数

4

回転可能な結合

10

名前と識別子

異性体SMILES

C1CCC(CC1)NC2=C(C=C(C=C2)S(=O)(=O)NCCN3CCNCC3)NCC4=CC=CC=C4

PubChem CID

137701965

分子量

471.66

化学的性質と物理的性質

• DMSO（mg / mL） 最大溶解度: 94
• DMSO（mM） 最大溶解度: 199.296103125133
• 水（mg / mL） 最大溶解度: ＜1