UCN-02 - ≥98% , Protein kinase C (PKC) inhibitor, CAS No.121569-61-7, Protein kinase C (PKC) inhibitor

CAS: 121569-61-7 Cat. No.: U329559 分子式: C28H26N4O4 分子量: 482.5 PubChem CID: 4616292
注文可能
GRADE & PURITY ≥98%
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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Size
USA
ドイツ (EU)*
Price
Qty
1mg
U329559-1mg
受注生産 · 8~12週間
$536.90
500μg
U329559-500μg
受注生産 · 8~12週間
$307.90
5mg
U329559-5mg
受注生産 · 8~12週間
$2,144.90
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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

概要

UCN-02 is a indolocarbazole isolated from a high staurosporine-producing Streptomyces culture. UCN-02 is isolated as a minor co-metabolite of high staurosporine-producing strains of selected actinomycetes. Although less selective than its isomer UCN-01, UCN-02 exhibits comparable activity and probably acts by similar mechanisms. UCN-02 is an inhibitor of PKC α, PKC β, PKC δ, PKCε and PKC γ.

Specifications

仕様と純度
≥98%
保管条件
Store at -20°C
入荷
Ice chest + Ice pads
この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。
アクションタイプ
INHIBITOR
作用メカニズム
Protein kinase C (PKC) inhibitor
純度
≥98%
名前と識別子
カノニカル・スマイル
CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(NC6=O)O)NC)OC
IUPAC Name
18-hydroxy-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one
InChIKey
PBCZSGKMGDDXIJ-UHFFFAOYSA-N
INCHI
1S/C28H26N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,27,29,34H,12H2,1-3H3,(H,30,33)
異性体SMILES
CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(NC6=O)O)NC)OC
PubChem CID
4616292
分子量
482.5

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
分類Indoles and derivatives
SubclassCarbazoles
Intermediate Tree Nodes Pyrrolocarbazoles
Direct ParentIndolocarbazoles
Alternative Parents Pyrrolo[2,3-a]carbazoles  Pyrroloindoles  Isoindolones  Indoles  Benzenoids  Oxanes  Pyrroles  Heteroaromatic compounds  Lactams  Secondary carboxylic acid amides  Amino acids and derivatives  Dialkylamines  Dialkyl ethers  Alkanolamines  Azacyclic compounds  Oxacyclic compounds  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Indolocarbazole - Pyrrolo[2,3-a]carbazole - Pyrroloindole - Isoindolone - Indole - Isoindoline - Isoindole or derivatives - Benzenoid - Oxane - Heteroaromatic compound - Pyrrole - Amino acid or derivatives - Carboxamide group - Secondary carboxylic acid amide - Lactam - Alkanolamine - Carboxylic acid derivative - Dialkyl ether - Secondary aliphatic amine - Ether - Oxacycle - Azacycle - Secondary amine - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Amine - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
説明This compound belongs to the class of organic compounds known as indolocarbazoles. These are polycyclic aromatic compounds containing an indole fused to a carbazole.
External Descriptors an indolocarbazole alkaloid
3 D構造
インタラクティブ化学構造モデル





関連ターゲット(人間)
STK10 Tchem Serine/threonine-protein kinase 10 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SIK2 Tchem Serine/threonine-protein kinase SIK2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SEPT9 Tchem Septin-9 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PKN1 Tchem Serine/threonine-protein kinase N1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PRKCB Tchem Protein kinase C beta type (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MARK2 Tchem Serine/threonine-protein kinase MARK2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MARK3 Tchem MAP/microtubule affinity-regulating kinase 3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MARK4 Tchem MAP/microtubule affinity-regulating kinase 4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Tchem Uncharacterized protein FLJ45252 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PRKAG2 Tchem 5'-AMP-activated protein kinase subunit gamma-2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CHEK1 Tchem Serine/threonine-protein kinase Chk1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CHEK2 Tchem Serine/threonine-protein kinase Chk2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PAK4 Tchem Serine/threonine-protein kinase PAK 4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PAK6 Tchem Serine/threonine-protein kinase PAK 6 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
関連ターゲット(非人間)
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
作用メカニズム
証明書(CoA、COO、BSE/TSEと分析図)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
化学的性質と物理的性質
溶解度Soluble in DMSO, ethanol, ethyl acetate, and DMF.
屈折率n20D1.83 (Predicted)
沸点(°C)705.741° C at 760 mmHg (Predicted)
融点(°C)314.42° C (Predicted)
分子量482.500 g/mol
XLogP32.700
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass482.195 Da
Monoisotopic Mass482.195 Da
Topological Polar Surface Area89.700 Ų
Heavy Atom Count36
Formal Charge0
Complexity935.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count5
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
ソリューション計算機
レビュー

顧客レビュー

よくある質問

What is the purity of this product?
This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.
How should this product be stored?
Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.
How is this product shipped?
This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 121569-61-7, the molecular formula is C28H26N4O4, and the molecular weight is 482.5 g/mol. InChIKey PBCZSGKMGDDXIJ-UHFFFAOYSA-N.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

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