≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
ULK-101 ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively.
Targets
ULK1 (Cell-free assay); ULK2 (Cell-free assay) 8.3 nM; 30 nM
In vitro
ULK-101 suppresses autophagy induction and autophagic flux in response to different stimuli. ULK-101 sensitizes KRAS mutant lung cancer cells to nutrient stress.
Cell Research(from reference)
Cell lines：U2OS cells
Concentrations：5 μM
Incubation Time：2.5 h
| ALogP | 4.363 |
|---|---|
| HBD数 | 1 |
| 回転可能な結合 | 6 |
| パブケム・シド | 504773505 |
|---|---|
| パブケム・シド・ウル | https://pubchem.ncbi.nlm.nih.gov/substance/504773505 |
| カノニカル・スマイル | C1CC1C(C(F)(F)F)NC(=O)C2=CC(=CS2)C3=C4N=CC(=CN4N=C3)C5=CC=C(C=C5)F |
| IUPAC Name | N-[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]-4-[6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl]thiophene-2-carboxamide |
| InChIKey | PFZRXJIYAFANHP-IBGZPJMESA-N |
| INCHI | 1S/C22H16F4N4OS/c23-16-5-3-12(4-6-16)15-8-27-20-17(9-28-30(20)10-15)14-7-18(32-11-14)21(31)29-19(13-1-2-13)22(24,25)26/h3-11,13,19H,1-2H2,(H,29,31)/t19-/m0/s1 |
| 異性体SMILES | C1CC1[C@@H](C(F)(F)F)NC(=O)C2=CC(=CS2)C3=C4N=CC(=CN4N=C3)C5=CC=C(C=C5)F |
| PubChem CID | 137628686 |
| 分子量 | 460.45 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| 分類 | Pyrazolopyrimidines |
| Subclass | Pyrazolo[1,5-a]pyrimidines |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Pyrazolo[1,5-a]pyrimidines |
| Alternative Parents | Thiophene carboxamides Fluorobenzenes Pyrimidines and pyrimidine derivatives N-acyl amines Pyrazoles Heteroaromatic compounds Carboxylic acid amides Azacyclic compounds Organosulfur compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organofluorides Organic oxides Hydrocarbon derivatives Alkyl fluorides |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Pyrazolo[1,5-a]pyrimidine - Thiophene carboxylic acid or derivatives - Thiophene carboxamide - Halobenzene - Fluorobenzene - Benzenoid - Pyrimidine - N-acyl-amine - Monocyclic benzene moiety - Heteroaromatic compound - Thiophene - Pyrazole - Azole - Carboxamide group - Azacycle - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Alkyl halide - Alkyl fluoride - Aromatic heteropolycyclic compound |
| 説明 | This compound belongs to the class of organic compounds known as pyrazolo[1,5-a]pyrimidines. These are aromatic heterocyclic compounds containing a pyrazolo[3,4-d]pyrimidine ring system, which consists of a pyrazole ring fused to and sharing exactly one nitrogen atom with a pyrimidine ring. |
| External Descriptors | Not available |
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| 溶解度 | Solubility (25°C) In vitro DMSO: 92 mg/mL (199.8 mM); Water: Insoluble; Ethanol: Insoluble; |
|---|---|
| DMSO（mg / mL） 最大溶解度 | 92 |
| DMSO（mM） 最大溶解度 | 199.804539037898 |
| 水（mg / mL） 最大溶解度 | ＜1 |
| 分子量 | 460.400 g/mol |
| XLogP3 | 4.900 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 5 |
| Exact Mass | 460.098 Da |
| Monoisotopic Mass | 460.098 Da |
| Topological Polar Surface Area | 87.500 Ų |
| Heavy Atom Count | 32 |
| Formal Charge | 0 |
| Complexity | 685.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 1 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
K2216519