UNC6852 - ≥99% , CAS No.2688842-08-0

CAS: 2688842-08-0 Cat. No.: U651045 分子式: C₄₃H₄₈N₁₀O₆S 分子量: 832.97

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Application

PROTAC

概要

UNC6852 is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC and contains an EED (embryonic ectoderm development) ligand and a von Hippel-Lindau ligand, with an IC 50 of 247 nM for EED

In Vitro

UNC6852 mediates PRC2 degradation. UNC6852 displays no cellular toxicity at concentrations up to 30 μM for HeLa Cells. UNC6852 (10 μM; 1-72 hours) results in a decrease in the levels of both EED and EZH2. UNC6852 facilitates PRC2 degradation via VHL recruitment. UNC6852 selectively degrades EED and EZH2. UNC6852 reduces H3K27me3 levels and DLBCL cell proliferation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: DLBCL Cells Concentration: 3 μM Incubation Time: 0 -10 days Result: Exhibited anti-proliferative effects. Western Blot AnalysisCell Line: HeLa Cells Concentration: 10 μM Incubation Time: 1 hours, 4 hours, 8 hours, 10 hours, 16 hours, 20 hours, 24 hours, 48 hours, 72 hours Result: Resulted in a decrease in the levels of both EED and EZH2.

Form:Solid

IC50& Target:IC50: 247 nM (EED)

Specifications

仕様と純度

≥99%

生化学的・生理学的メカニズム

UNC6852 is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC and contains an EED (embryonic ectoderm development) ligand and a von Hippel-Lindau ligand, with an IC 50 of 247 nM for EED.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥99%

名前と識別子

• 分子量: 832.97

化学的性質と物理的性質

• 溶解度: DMSO : 100 mg/mL (120.05 mM; Need ultrasonic)