UNC6852 - 10mM in DMSO , CAS No.2688842-08-0

CAS: 2688842-08-0 Cat. No.: U656509 分子式: C₄₃H₄₈N₁₀O₆S 分子量: 832.97

グレード＆純度 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

UNC6852 is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC and contains an EED (embryonic ectoderm development) ligand and a von Hippel-Lindau ligand, with an IC 50 of 247 nM for EED

In Vitro

UNC6852 mediates PRC2 degradation. UNC6852 displays no cellular toxicity at concentrations up to 30 μM for HeLa Cells. UNC6852 (10 μM; 1-72 hours) results in a decrease in the levels of both EED and EZH2. UNC6852 facilitates PRC2 degradation via VHL recruitment. UNC6852 selectively degrades EED and EZH2. UNC6852 reduces H3K27me3 levels and DLBCL cell proliferation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: DLBCL Cells Concentration: 3 μM Incubation Time: 0 -10 days Result: Exhibited anti-proliferative effects. Western Blot AnalysisCell Line: HeLa Cells Concentration: 10 μM Incubation Time: 1 hours, 4 hours, 8 hours, 10 hours, 16 hours, 20 hours, 24 hours, 48 hours, 72 hours Result: Resulted in a decrease in the levels of both EED and EZH2.

IC50& Target:IC50: 247 nM (EED)

仕様

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

UNC6852 is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC and contains an EED (embryonic ectoderm development) ligand and a von Hippel-Lindau ligand, with an IC 50 of 247 nM for EED.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

名前と識別子

分子量

832.97

よくある質問

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2688842-08-0, the molecular formula is C43H48N10O6S, and the molecular weight is 832.97 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.