Urolithin C - Moligand™, ≥99% , CAS No.165393-06-6

CAS: 165393-06-6 Cat. No.: U649769 分子式: C₁₃H₈O₅ 分子量: 244.20 PubChem CID: 60198001

GRADE & PURITY Moligand™, ≥99%

Synonyms

3,8,9-Trihydroxy-6H-benzo[c]chromen-6-one | 3,8,9-Trihydroxy-6H-dibenzo[b,d]pyran-6-one | 3,8,9-Trihydroxyurolithin

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion . Urolithin C is a L-type Ca 2+ channel opener and enhances Ca 2+ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates reactive oxygen species (ROS) formation

In Vitro

Urolithin C (20-100 μM; 1 hour; INS-1 cells) treatment enhances glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation in INS-1 β-cells. Urolithin C significantly inhibits the proliferation of PC12 cells. Urolithin C treatment actively increases the lactate dehydrogenase (LDH) release and lipid peroxidation malondialdehyde (MDA), stimulates reactive oxygen species (ROS) formation and mitochondrial membrane depolarization, and caused calcium dyshomeostasis. Urolithin C treatment induces apoptosis and S phase cell cycle arrest. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: INS-1 cells Concentration: 20 μM, 100 μM Incubation Time: 1 hour Result: Enhanced glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation.

In Vivo

The pharmacokinetics of Urolithin C (10 mg/kg; intraperitoneal administration) in male Wistar rat (140-160 g) are studied. The half-life of the terminal part is 11.3 h and the total clearance (CL/F) is 3.41 L/h/kg. The initial volume of distribution (V 1 /F) and the steady-state volume of distribution (Vss/F) are 0.831 L/kg and 55.6 L/kg, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:Insulin secretion, L-type Ca 2+ channel, Reactive oxygen species (ROS),Apoptosis

Specifications

同義語

3,8,9-Trihydroxy-6H-benzo[c]chromen-6-one | 3,8,9-Trihydroxy-6H-dibenzo[b,d]pyran-6-one | 3,8,9-Trihydroxyurolithin

仕様と純度

Moligand™, ≥99%

生化学的・生理学的メカニズム

Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion . Urolithin C is a L-type Ca 2+ channel opener and enhances Ca 2+ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pat

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

アクションタイプ

ACTIVATOR

純度

≥99%

名前と識別子

• パブケム・シド: 528767610
• 異性体SMILES: C1=CC2=C(C=C1O)OC(=O)C3=CC(=C(C=C23)O)O
• PubChem CID: 60198001
• 分子量: 244.20

作用メカニズム

化学的性質と物理的性質

• 溶解度: DMSO : 50 mg/mL (204.75 mM; Need ultrasonic)
• 分子量: 244.200 g/mol
• XLogP3: 2.000
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 244.037 Da
• Monoisotopic Mass: 244.037 Da
• Topological Polar Surface Area: 87.000 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 344.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1