VGX-1027 (Git-27) - Moligand™, ≥98% , CAS No.6501-72-0

CAS: 6501-72-0 Cat. No.: V275496 分子式: C₁₁H₁₁NO₃ 分子量: 205.21 EC番号: 636-241-9 PubChem CID: 10798271

GRADE & PURITY Moligand™, ≥98%

Synonyms

rac-[(5R)-3-phenyl-4,5-dihydro-1,2-oxazol-5-yl]acetic acid | 4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid | VGX-1027;GIT 27 | GLS1027 | GLS-1027 | 2-Isoxazoline-5-acetic acid, 3-phenyl- | 4,5-DIHYDRO-3-PHENYL-5-ISOXAZOLEACETIC ACID | AKT814N13R | AS-65356 |

Storage

Store at -20°C,Argon charged,Desiccated

Shipped In

Ice chest + Ice pads

概要

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Specifications

同義語

rac-[(5R)-3-phenyl-4,5-dihydro-1,2-oxazol-5-yl]acetic acid | 4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid | VGX-1027;GIT 27 | GLS1027 | GLS-1027 | 2-Isoxazoline-5-acetic acid, 3-phenyl- | 4,5-DIHYDRO-3-PHENYL-5-ISOXAZOLEACETIC ACID | AKT814N13R | AS-65356 |

仕様と純度

Moligand™, ≥98%

生化学的・生理学的メカニズム

Immunomodulatory agent. TLR4 inhibitor. TLR4 and TLR 2/6 signaling pathway modulator. Inhibits inflammatory antigen presentation. Inhibits IL1-β, IL-10, IFN-γ and TNF-α secretion. Shows anti-inflammatory effects in vivo. Orally active.

ソース

Synthetic

保管条件

Store at -20°C,Argon charged,Desiccated

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

注

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

純度

≥98%

製品の性質

• ALogP: 1.3

名前と識別子

• パブケム・シド: 504765623
• パブケム・シド・ウル: https://pubchem.ncbi.nlm.nih.gov/substance/504765623
• カノニカル・スマイル: C1C(ON=C1C2=CC=CC=C2)CC(=O)O
• IUPAC Name: 2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid
• InChIKey: MUFJHYRCIHHATF-UHFFFAOYSA-N
• INCHI: 1S/C11H11NO3/c13-11(14)7-9-6-10(12-15-9)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H,13,14)
• 異性体SMILES: C1C(ON=C1C2=CC=CC=C2)CC(=O)O
• PubChem CID: 10798271
• 分子量: 205.21

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • 分類 Benzene and substituted derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• 分類: Benzene and substituted derivatives
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzene and substituted derivatives
• Alternative Parents: Isoxazolines Oxacyclic compounds Monocarboxylic acids and derivatives Carboxylic acids Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Monocyclic benzene moiety - Isoxazoline - Carboxylic acid derivative - Carboxylic acid - Oxacycle - Azacycle - Organoheterocyclic compound - Monocarboxylic acid or derivatives - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Carbonyl group - Aromatic heteromonocyclic compound
• 説明: This compound belongs to the class of organic compounds known as benzene and substituted derivatives. These are aromatic compounds containing one monocyclic ring system consisting of benzene.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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HEK293 (82097 Activities)

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FEN1 Tchem Flap endonuclease 1 (12055 Activities)

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関連ターゲット（非人間）

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GCN5 Histone acetyltransferase GCN5 (89 Activities)

Discover Target: GCN5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

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pfk 6-phospho-1-fructokinase (7870 Activities)

Discover Target: pfk

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作用メカニズム

化学的性質と物理的性質

• 溶解度: Soluble in ethanol to 100 mM and in DMSO to 100 mM
• 感度: Air Sensitive,Heat Sensitive
• 融点（°C）: 157.0 to 161.0 °C
• 分子量: 205.210 g/mol
• XLogP3: 1.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 205.074 Da
• Monoisotopic Mass: 205.074 Da
• Topological Polar Surface Area: 58.900 Ų
• Heavy Atom Count: 15
• Formal Charge: 0
• Complexity: 269.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

よくある質問

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C, desiccated, under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 6501-72-0, the molecular formula is C11H11NO3, and the molecular weight is 205.21 g/mol. InChIKey MUFJHYRCIHHATF-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.