VRK-IN-1 - Moligand™, ≥99% , CAS No.2378855-09-3

CAS: 2378855-09-3 Cat. No.: V647791 分子式: C₁₈H₁₁F₄NO₂ 分子量: 349.28 PubChem CID: 155511407

GRADE & PURITY Moligand™, ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1) , with an IC 50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders

In Vitro

VRK-IN-1 binds to VRK1-FL by enthalpy-driven, with a K d of 190 nM. VRK-IN-1 (0.4-25 μM; 24 h) slightly decreases the viability of human HeLa cells at the concentration of 3.2 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: 150 nM (VRK1)

Specifications

仕様と純度

Moligand™, ≥99%

生化学的・生理学的メカニズム

VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1) , with an IC 50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

等級

Moligand™

純度

≥99%

名前と識別子

パブケム・シド

508817327

カノニカル・スマイル

CC1=C(C=C(C=N1)C2=CC(=C(C(=C2)F)O)F)C3=CC(=C(C(=C3)F)O)F

IUPAC Name

4-[5-(3,5-difluoro-4-hydroxyphenyl)-6-methylpyridin-3-yl]-2,6-difluorophenol

InChIKey

PMRGRXLXKYUDIH-UHFFFAOYSA-N

INCHI

1S/C18H11F4NO2/c1-8-12(10-5-15(21)18(25)16(22)6-10)2-11(7-23-8)9-3-13(19)17(24)14(20)4-9/h2-7,24-25H,1H3

異性体SMILES

CC1=C(C=C(C=N1)C2=CC(=C(C(=C2)F)O)F)C3=CC(=C(C(=C3)F)O)F

PubChem CID

155511407

分子量

349.28

関連ターゲット（人間）

HeLa (62764 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

VRK1 Tbio Serine/threonine-protein kinase VRK1 (258 Activities)

Discover Target: VRK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

作用メカニズム

化学的性質と物理的性質

• 溶解度: DMSO : 100 mg/mL (286.30 mM; Need ultrasonic)