VU 0364439 - 10mM in DMSO , CAS No.1246086-78-1

CAS: 1246086-78-1 Cat. No.: V408515 分子式: C₁₈H₁₃Cl₂N₃O₃S 分子量: 422.29 PubChem CID: 46934289

グレード＆純度 10mM in DMSO

Synonyms

2-Pyridinecarboxamide, N-[3-chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

Information

VU 0364439 is amGlu4positive allosteric modulator (PAM), withEC50of 19.8 nM.
In vitro

In vivo

VU 0364439 possess less than ideal PK properties preventing their use as in vivo tools. It shows better stability in HLM (63% remaining) than RLM (2% remaining).
Cell Data

cell lines：HeLa, HCT116, HT29, LOVO, DU145, and NHDF cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

仕様

同義語

2-Pyridinecarboxamide, N-[3-chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]-

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

名前と識別子

異性体SMILES

C1=CC=C(C(=C1)NS(=O)(=O)C2=C(C=C(C=C2)NC(=O)C3=CC=CC=N3)Cl)Cl

PubChem CID

46934289

分子量

422.29

関連ターゲット（人間）

GRM4 Tchem Metabotropic glutamate receptor 4 (4 Activities)

Discover Target: GRM4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

化学的性質と物理的性質

• 溶解度: Solubility (25°C) In vitro DMSO: 58 mg/mL (199.69 mM); Ethanol: 58 mg/mL (199.69 mM); Water: Insoluble