VU6000918 - ≥99% , CAS No.2101737-32-8

CAS: 2101737-32-8 Cat. No.: V646544 分子式: C₁₈H₁₇F₂N₅OS 分子量: 389.42

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

VU6000918 is a muscarinic acetylcholine (M4) positive allosteric modulator, with an EC 50 of 19 nM for hM4

In Vitro

VU6000918 demonstrates statistically significant AHL reversal (18%) from a low oral dose of 0.03 mg/kg and reaches maximal reversal (74%) from a 3 mg/kg dose, with a resulting in vivo plasma EC 50 of 74 nM (0.66 nM unbound) based on terminal concentrations measured in the study animals (1.5 hr post-administration of 17j). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:EC50: 19 nM (hM4)

Specifications

仕様と純度

≥99%

生化学的・生理学的メカニズム

VU6000918 is a muscarinic acetylcholine (M4) positive allosteric modulator, with an EC 50 of 19 nM for hM4.

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥99%

名前と識別子

• カノニカル・スマイル: O=C(C1=C(N)C2=C(C)C(C)=NN=C2S1)NC3CN(C4=CC=CC(F)=C4F)C3
• 分子量: 389.42

化学的性質と物理的性質

• 溶解度: DMSO : 125 mg/mL (320.99 mM; Need ultrasonic)