VU6012962 - 10mM in DMSO , CAS No.2313526-86-0

CAS: 2313526-86-0 Cat. No.: V656429 分子式: C₂₁H₁₉F₃N₄O₄ 分子量: 448.40

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

VU6012962 is an orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 negative allosteric modulator ( mGlu 7 NAM) with an IC 50 of 347 nM

In Vitro

VU6012962 is highly selective for mGlu7 versus the other seven mGlu receptor subtypes. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

VU6012962 (1-10 mg/kg; i.p. injection; 60 minutes prior to testing) decreases anxiety in the elevated zero maze (EZM) assay in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57Bl/6J male mice (8 weeks old) Dosage: 1, 3, and 10 mg/kg Administration: I.p. injections; 60 minutes prior to testing Result: Increased total time spent in the open arms at a dose of 3 mg/kg. 10 mg/kg did cause a decrease in overall locomotion.

IC50& Target:mGlu7 347 nM (IC 50 )

Specifications

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

VU6012962 is an orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 negative allosteric modulator ( mGlu 7 NAM) with an IC 50 of 347 nM.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

名前と識別子

• 異性体SMILES: COC1=C(C=CC(=C1)C(=O)NC2=C(C=CC(=C2)OC(F)(F)F)N3C=NC=N3)OCC4CC4
• 分子量: 448.40