WEE1-IN-5 - ≥99% , CAS No.2243882-74-6

CAS: 2243882-74-6 Cat. No.: W648831 分子式: C₂₆H₂₈Cl₂N₆O 分子量: 511.45

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

WEE1-IN-5 is a potent WEE1 inhibitor with an IC 50 value of 0.8 nM. WEE1-IN-5 inhibits phospho-CDC2. WEE1-IN-5 abrogates the G2 check point, increasing sensitivity to DNA damaging agents in cancer cells. WEE1-IN-5 can be used for researching anticancer

In Vitro

WEE1-IN-5 exhibits an EC 50 of 188 nM in pCDC2 and an IC 50 shift for CYP3A4/5. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

WEE1-IN-5 (5mg/kg for PO; 1 mg/kg for IV; single dosage) exhibits a CL of 14 mL/min/kg, an AUC int 1324 h·ng/mL and bioavailability of 35% in SD rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC 50 : 0.8 nM (WEE1), 188 nM (CDC2)

Specifications

仕様と純度

≥99%

生化学的・生理学的メカニズム

WEE1-IN-5 is a potent WEE1 inhibitor with an IC 50 value of 0.8 nM. WEE1-IN-5 inhibits phospho-CDC2. WEE1-IN-5 abrogates the G2 check point, increasing sensitivity to DNA damaging agents in cancer cells. WEE1-IN-5 can be used for researching anticancer [

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥99%

名前と識別子

カノニカル・スマイル

O=C1C2=CN=C(NC3=CC=C(C4CCN(CC4)C)C(C)=C3)N=C2N(CN1C5=C(Cl)C=CC=C5Cl)C

分子量

511.45

化学的性質と物理的性質

• 溶解度: DMSO : 20 mg/mL (39.10 mM; ultrasonic and warming and heat to 60°C)