WEHI-9625 - ≥99% , CAS No.2595314-46-6

CAS: 2595314-46-6 Cat. No.: W650101 分子式: C₃₄H₂₇NO₅S₂ 分子量: 593.71

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

概要

WEHI-9625 is a tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC 50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK . WEHI-9625 is completely inactive against both human BAK and the closely related apoptosis effector BAX

In Vitro

WEHI-9625 (0-10 µM; Mcl1 −/− Bax −/− MEFs cells) treatment could prevent cell death mediated by BAK and potently inhibits BIM BH3-induced loss of mitochondrial membrane potential in Bax −/− , but not Bak −/− , cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Mcl1 −/− Bax −/− MEFs cells with ABT-737-pretreated Concentration: 0-10 µM Incubation Time: Result: Could prevent cell death.

In Vivo

WEHI-9625 demonstrates that blocking apoptosis at an early stage was both advantageous and pharmacologically tractable . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:Bak Bax

Specifications

仕様と純度

≥99%

生化学的・生理学的メカニズム

WEHI-9625 is a tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC 50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK . WEHI-9625 is completely inactive against both human BAK and the cl

保管条件

Store at -20°C

入荷

Ice chest + Ice pads

この製品は冷冷この冷このこの製品の運送が必要です。地上およびその他の経済サービスは利用できません。

純度

≥99%

名前と識別子

カノニカル・スマイル

O=C(C(S1)=CC(CS2(=O)=O)=C1C3=C2C=C(C4=CC=CC=C4C(C5=CC=C(OC)C=C5)=O)C=C3)NCC6=CC=C(C)C=C6

分子量

593.71

化学的性質と物理的性質

• 溶解度: DMSO : 100 mg/mL (168.43 mM; Need ultrasonic)