WEHI-9625 - 10mM in DMSO , CAS No.2595314-46-6

CAS: 2595314-46-6 Cat. No.: W656131 Molecular Weight: 593.71

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

WEHI-9625 is a tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC 50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK . WEHI-9625 is completely inactive against both human BAK and the closely related apoptosis effector BAX

In Vitro

WEHI-9625 (0-10 µM; Mcl1 −/− Bax −/− MEFs cells) treatment could prevent cell death mediated by BAK and potently inhibits BIM BH3-induced loss of mitochondrial membrane potential in Bax −/− , but not Bak −/− , cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Mcl1 −/− Bax −/− MEFs cells with ABT-737-pretreated Concentration: 0-10 µM Incubation Time: Result: Could prevent cell death.

In Vivo

WEHI-9625 demonstrates that blocking apoptosis at an early stage was both advantageous and pharmacologically tractable . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Bak Bax

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

WEHI-9625 is a tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC 50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK . WEHI-9625 is completely inactive against both human BAK and the cl

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Molecular Weight: 593.71