YK11 - 10mM in DMSO , CAS No.1370003-76-1

CAS: 1370003-76-1 Cat. No.: Y656702 分子式: C₂₅H₃₄O₆ 分子量: 430.53 PubChem CID: 119058028

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

概要

YK11 is a partial agonist of androgen receptor , with osteogenic activity.

In Vitro

YK11 is a partial agonist of androgen receptor, and induces myogenic differentiation of C2C12 Cells at 500 nM via Fst mRNA upregulation by AR. YK11 enhances Myf5 and myogenin mRNA expression, but requires high concentrations (YK11, 100?nM or 500?nM). YK11 (0.5?μM) increases the cell growth of osteoblastic MC3T3-E1 cells, and enhances ALP activity via AR. YK11 also elevates osteoprotegerin mRNA expression (0.5?μM) and dose-dependently increases osteocalcin mRNA expression (0.1-1.0 μM). In addition, YK11 enhances phosphorylation of Akt protein via rapid non-genomic signaling. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Androgen receptor

Specifications

仕様と純度

10mM in DMSO

生化学的・生理学的メカニズム

YK11 is a partial agonist of androgen receptor , with osteogenic activity.

保管条件

Store at -80°C

入荷

Dry ice packs + Cold packs

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名前と識別子

• 異性体SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@]24/C(=C\C(=O)OC)/OC(O4)(C)OC)CCC5=CC(=O)CC[C@H]35
• 代替CAS番号: 1370003-76-1
• PubChem CID: 119058028
• MeSH用語: 17,20-((1-methoxyethylidene)bis(oxy))-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester;YK11 cpd
• 分子量: 430.53