Cilengitide acetate - ≥98% , CAS No.188968-51-6(free base)

CAS: 188968-51-6(free base) Cat. No.: C1374020 Formula: C₂₇H₄₀N₈O₇(free base) Molecular Weight: 588.66(free base)

GRADE & PURITY ≥98%

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Cilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM, respectively; ~10-fold selectivity against gpIIbIIIa.

Specifications

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Potent and selective inhibitor of integrinsαvβ3andαvβ5(IC50values are 4.1 and 70 nM, respectively). Exhibits ~10-fold selectivity over gpIIb/IIIa. Increases endothelial monolayer permeability. Also exhibits antiangiogenic activity.

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 528775665
• Molecular Weight: 588.66(free base)

Chemical and Physical Properties

• Solubility: Soluble to 10 (mg/mL) in water}
• Sensitivity: Light sensitive
• Molecular Weight: 588.700 g/mol
• XLogP3: -1.000
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 9
• Exact Mass: 588.302 Da
• Monoisotopic Mass: 588.302 Da
• Topological Polar Surface Area: 238.000 Ų
• Heavy Atom Count: 42
• Formal Charge: 0
• Complexity: 1020.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 4
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1