ERK inhibitor - ≥95% , CAS No.1049738-54-6

CAS: 1049738-54-6 Cat. No.: E335372 Formula: C₁₄H₁₆N₂O₃S・HCl Molecular Weight: 328.81

GRADE & PURITY ≥95%

Synonyms

3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione, HCl

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

ERK Inhibitor is a cell-permeable thiazolidinedione compound that shows anti-proliferative properties. Binds preferentially to ERK2 with a KD of ~5 μM and prevents its interaction with protein substrates. The compound has been shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1 in HeLa cells, while exhibiting minimal effect on ERK1/2 phosphorylation by MEK1/2.

Specifications

Synonyms

3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione, HCl

Specifications & Purity

≥95%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥95%

Names and Identifiers

• Pubchem Sid: 504768383
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504768383
• Canonical Smiles: CCOC1=CC=C(C=C1)C=C2C(=O)N(C(=O)S2)CCN.Cl
• IUPAC Name: 3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione;hydrochloride
• InChIKey: PQVLWVGMXJPJLG-UHFFFAOYSA-N
• INCHI: 1S/C14H16N2O3S.ClH/c1-2-19-11-5-3-10(4-6-11)9-12-13(17)16(8-7-15)14(18)20-12;/h3-6,9H,2,7-8,15H2,1H3;1H
• Isomeric SMILES: CCOC1=CC=C(C=C1)C=C2C(=O)N(C(=O)S2)CCN.Cl
• WGK Germany: 3
• Molecular Weight: 328.81
• Reaxy-Rn: 22507528
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=22507528&ln=

Chemical and Physical Properties

• Solubility: Soluble in DMSO (≥4 mg/mL).
• x_refractive_index: n20D~1.65 (Predicted)

Frequently Asked Questions

What is the purity of this product?

This product is supplied at ≥95% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1049738-54-6, the molecular formula is C14H16N2O3S?HCl, and the molecular weight is 328.81 g/mol. InChIKey PQVLWVGMXJPJLG-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.