1-(4-Fluorophenyl)pyrazole: Properties, Uses & FAQs

1-(4-fluorophenyl)pyrazole is a fluorinated N-arylpyrazole heterocyclic compound widely used as a synthetic building block and research reagent in medicinal chemistry and drug discovery programs.

Chemical Name

1-(4-fluorophenyl)-1H-pyrazole

SKU / Product Code

P729687

Molecular Formula

C9H7FN2

Molecular Weight

162.17 g/mol

Core Scaffold

N-arylpyrazole with para-fluorophenyl substitution

Key Application

Synthetic intermediate and building block in medicinal chemistry

What Is 1-(4-Fluorophenyl)pyrazole?

1-(4-Fluorophenyl)pyrazole (SKU: P729687) is a five-membered nitrogen-containing heterocyclic compound in which a pyrazole ring is substituted at the N1 position with a para-fluorophenyl group. The pyrazole ring system contains two adjacent nitrogen atoms, conferring hydrogen-bond accepting capability, moderate aromaticity, and a planar geometry that facilitates stacking interactions with biological targets. The introduction of a fluorine atom at the para position of the phenyl ring is a common medicinal chemistry strategy to modulate lipophilicity, metabolic stability, and membrane permeability of candidate molecules.

The compound is catalogued under Aladdin Scientific SKU P729687 and is supplied as a research-grade reagent suitable for use as a synthetic building block or reference standard in laboratory settings.

Physical and Chemical Properties

1-(4-Fluorophenyl)pyrazole has the molecular formula C9H7FN2 and a molecular weight of approximately 162.17 g/mol. The compound features a planar, conjugated framework resulting from the N-aryl linkage between the para-fluorophenyl ring and the pyrazole heterocycle. Key physicochemical characteristics relevant to researchers include:

• Molecular Formula: C9H7FN2
• Molecular Weight: ~162.17 g/mol
• Functional Groups: Aromatic C–F bond, N-aryl bond, pyrazole N=N–C system
• Solubility: Expected to show moderate solubility in common organic solvents such as DMSO, ethanol, and dichloromethane; limited aqueous solubility (verify with Certificate of Analysis)

The fluorine substituent at the para position exerts a strong inductive electron-withdrawing effect on the phenyl ring while contributing minimally to steric bulk, making it a valuable handle for fine-tuning electronic properties in analog synthesis programs.

Research Applications and Uses

N-Arylpyrazoles bearing fluorinated phenyl groups are widely encountered as core scaffolds or key intermediates in medicinal chemistry and agrochemical research. Researchers commonly use 1-(4-fluorophenyl)pyrazole in the following contexts:

• Synthetic Intermediate: As a precursor or building block for the construction of more complex pyrazole-containing target molecules through electrophilic aromatic substitution, directed metalation, or cross-coupling reactions at the pyrazole C4 or C5 positions.
• Scaffold for Drug Discovery: The N-arylpyrazole motif appears in a range of bioactive compounds; this fluorinated variant can serve as a starting material for SAR (structure–activity relationship) exploration.
• Reference Standard: As an analytical reference compound for characterization or method development in HPLC, NMR, or mass spectrometry workflows.
• Agrochemical Research: Fluorophenylpyrazole scaffolds are found in certain insecticidal and herbicidal candidates; this compound may serve as a model or intermediate in such programs.

Researchers should consult current literature for specific reaction conditions and biological assay protocols relevant to their programs.

Handling, Storage, and Safety Considerations

As with all research chemicals, 1-(4-fluorophenyl)pyrazole should be handled in accordance with standard laboratory safety practices. Researchers and lab managers should observe the following general guidelines:

• Personal Protective Equipment (PPE): Wear appropriate gloves, lab coat, and eye protection when handling this compound.
• Ventilation: Use a fume hood when weighing or working with the neat material to minimise inhalation exposure.
• Storage: Store in a cool, dry, well-ventilated area away from incompatible materials. Specific storage temperature recommendations should be confirmed from the product label and Certificate of Analysis supplied with the batch.
• Disposal: Dispose of waste in accordance with applicable local, national, and institutional regulations for chemical waste.

Always consult the Safety Data Sheet (SDS) provided by Aladdin Scientific for batch-specific hazard classifications, GHS pictograms, first-aid measures, and regulatory information before use.

Ordering and Availability

1-(4-Fluorophenyl)pyrazole is available from Aladdin Scientific under SKU P729687. Procurement teams and lab managers can place orders through the Aladdin Scientific website or by contacting the sales team directly. When ordering, please note:

• Confirm the required quantity and pack size to ensure adequate supply for your research program.
• Request a Certificate of Analysis (CoA) for the specific batch to verify purity, identity (NMR, MS), and any applicable physical data.
• For bulk quantities or custom requirements, contact Aladdin Scientific customer service to discuss pricing and lead times.
• Check current stock availability and pricing on the Aladdin Scientific product page, as these may vary.

For questions about shipping conditions, export regulations, or payment options, refer to the relevant sections of the Aladdin Scientific help centre or contact customer support directly.

Frequently asked questions

What is 1-(4-fluorophenyl)pyrazole used for in research?

1-(4-Fluorophenyl)pyrazole is primarily used as a synthetic building block and intermediate in medicinal chemistry, enabling the construction of more complex N-arylpyrazole-containing molecules via cross-coupling or directed metalation reactions. It can also serve as a reference standard in analytical method development and as a scaffold for structure–activity relationship studies in drug discovery programs.

What is the molecular weight and formula of 1-(4-fluorophenyl)pyrazole?

The molecular formula of 1-(4-fluorophenyl)pyrazole is C9H7FN2, with a molecular weight of approximately 162.17 g/mol. The structure consists of a pyrazole ring N-substituted with a para-fluorophenyl group.

How should 1-(4-fluorophenyl)pyrazole be stored?

This compound should be stored in a cool, dry, and well-ventilated area away from incompatible substances, following the recommendations on the product label and Certificate of Analysis. Always consult the Aladdin Scientific Safety Data Sheet for batch-specific storage and handling instructions.

What is the Aladdin Scientific SKU for 1-(4-fluorophenyl)pyrazole?

1-(4-Fluorophenyl)pyrazole is listed under SKU P729687 in the Aladdin Scientific catalogue. You can search for this code directly on the Aladdin Scientific website to access current pricing, stock availability, and the product datasheet.

Is 1-(4-fluorophenyl)pyrazole available in bulk quantities?

For bulk quantity requirements beyond standard catalogue pack sizes, please contact Aladdin Scientific customer service directly to discuss availability, lead times, and custom pricing for SKU P729687.

References

1. Aladdin Scientific product listing: 1-(4-fluorophenyl)pyrazole, SKU P729687. Aladdin Scientific (accessed 2024).
2. Clayden, J.; Greeves, N.; Warren, S. Organic Chemistry, 2nd ed.; Oxford University Press: Oxford, 2012. (General heterocyclic chemistry reference.)
3. Fluorine in Medicinal Chemistry and Chemical Biology; Ojima, I., Ed.; Wiley-Blackwell: Chichester, 2009. (Reference on fluorine effects in drug design.)

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.