2-(3,4-Difluorophenoxy)-N,N-dimethylethanamine: Handling & Use Guide

2-(3,4-Difluorophenoxy)-N,N-dimethylethanamine is a fluorinated tertiary amine building block widely employed in medicinal chemistry and organic synthesis, requiring careful handling procedures to ensure researcher safety and reagent integrity.

Product Name

2-(3,4-Difluorophenoxy)-N,N-dimethylethanamine

SKU

D191488

Molecular Formula

C10H13F2NO

Compound Class

Fluorinated tertiary amine / aryl ether

Primary Applications

Medicinal chemistry intermediate, organic synthesis building block

Recommended Storage

Cool, dry, well-ventilated area; store away from heat sources and incompatible materials

Chemical Identity and Properties

2-(3,4-Difluorophenoxy)-N,N-dimethylethanamine (SKU D191488) is a small-molecule tertiary amine featuring a 3,4-difluorophenoxy aryl ether moiety linked to a dimethylaminoethyl chain. The presence of two fluorine substituents at the 3- and 4-positions of the phenyl ring significantly modulates the electronic character of the aromatic system, enhancing metabolic stability and lipophilicity relative to the non-fluorinated analogue — properties that make fluorinated aryl ethers attractive scaffolds in drug discovery programs.

The dimethylamino group confers basicity to the molecule, making it amenable to salt formation and enabling its use as a nucleophilic nitrogen source in various coupling and alkylation reactions. Researchers should confirm exact physicochemical data (molecular weight, melting/boiling point, purity, and specific optical rotation if applicable) from the certificate of analysis supplied with each lot.

Safe Handling and Storage Procedures

Personal Protective Equipment (PPE): Always wear appropriate PPE when working with 2-(3,4-Difluorophenoxy)-N,N-dimethylethanamine. This includes chemical-resistant gloves (nitrile recommended), safety goggles or a face shield, and a laboratory coat. If there is a risk of vapour generation, work inside a certified fume hood.

Handling Precautions: Tertiary amines can be irritating to skin, eyes, and the respiratory tract. Avoid inhalation of vapours or aerosols and prevent contact with skin and mucous membranes. Use appropriate closed-system transfer techniques when weighing or transferring the compound to minimise exposure.

Storage: Store the reagent in a tightly sealed container in a cool, dry, and well-ventilated area, away from sources of heat, ignition, and incompatible reagents such as strong oxidising agents and strong acids. Consult the Safety Data Sheet (SDS) provided by Aladdin Scientific for specific hazard classifications, GHS pictograms, and first-aid measures applicable to this lot.

Disposal: Dispose of waste material in accordance with local, regional, and national regulations governing hazardous chemical waste. Do not pour down the drain without verifying compliance with applicable effluent regulations.

Applications in Research and Synthesis

2-(3,4-Difluorophenoxy)-N,N-dimethylethanamine serves primarily as a versatile building block and intermediate in medicinal chemistry and pharmaceutical research. Its difluorophenoxy scaffold is a recognised pharmacophore element found in various bioactive compounds, where fluorine substitution is deliberately introduced to improve binding affinity, membrane permeability, and resistance to cytochrome P450-mediated oxidative metabolism.

The dimethylaminoethoxy side chain is a common motif in CNS-active compounds and has been incorporated into molecules targeting a range of receptor classes. Synthetic chemists may employ this compound in nucleophilic aromatic substitution reactions, reductive amination sequences, or as a starting material for the preparation of more complex amine derivatives via N-demethylation, N-alkylation, or salt formation.

Researchers exploring structure–activity relationships (SAR) in fluorinated amine series will find this compound a useful reference or derivatisation point. Confirm compatibility with planned reaction conditions — including solvent systems, bases, and temperatures — prior to large-scale use.

Quality, Purity, and Lot-to-Lot Verification

Aladdin Scientific supplies 2-(3,4-Difluorophenoxy)-N,N-dimethylethanamine (D191488) with a certificate of analysis (CoA) for each production lot. The CoA typically documents identity confirmation by techniques such as NMR spectroscopy or mass spectrometry, and purity assessment by HPLC or GC. Researchers are advised to review the CoA upon receipt to verify that purity and identity meet the requirements of their specific assay or synthetic protocol.

For sensitive biological assays (e.g., receptor binding, enzyme inhibition, or cell-based screens), it is good laboratory practice to perform an independent purity check — particularly when the compound is used as a reference standard or key pharmacological tool. Storage under recommended conditions and use within the shelf-life period stated on the CoA will help maintain reagent quality over time.

Contact Aladdin Scientific technical support if analytical data are required beyond what is supplied with the standard CoA, or if custom purity grades are needed for specialised applications.

Frequently asked questions

What is the recommended storage condition for 2-(3,4-Difluorophenoxy)-N,N-dimethylethanamine (D191488)?

The compound should be stored in a tightly closed container in a cool, dry, and well-ventilated location, away from heat sources, ignition sources, and incompatible materials such as strong oxidisers and strong acids. Always refer to the lot-specific Safety Data Sheet for precise storage temperature recommendations.

What personal protective equipment should be used when handling this compound?

At minimum, wear nitrile gloves, safety goggles or a face shield, and a laboratory coat. Because tertiary amines can generate irritating vapours, all manipulations should be performed in a certified chemical fume hood to prevent inhalation exposure.

What are the primary synthetic uses of 2-(3,4-Difluorophenoxy)-N,N-dimethylethanamine?

This compound is primarily used as a building block and intermediate in medicinal chemistry. Its difluorophenoxy pharmacophore and dimethylaminoethyl chain make it suitable for nucleophilic aromatic substitution, reductive amination, N-alkylation, and salt-formation reactions, as well as for structure–activity relationship studies in fluorinated amine series.

How can I verify the purity and identity of the received lot?

Review the certificate of analysis (CoA) supplied with each lot, which documents identity by NMR or MS and purity by HPLC or GC. For critical applications such as reference standards in biological assays, an independent purity verification by your laboratory is recommended as good practice.

Is a Safety Data Sheet (SDS) available for D191488?

Yes. Aladdin Scientific provides a Safety Data Sheet for 2-(3,4-Difluorophenoxy)-N,N-dimethylethanamine (D191488). The SDS contains detailed information on hazard classification, GHS pictograms, first-aid measures, firefighting procedures, and disposal guidance. Contact Aladdin Scientific customer service or visit the product page to download the current SDS.

References

1. Aladdin Scientific. Product Data Sheet and Certificate of Analysis: 2-(3,4-Difluorophenoxy)-N,N-dimethylethanamine, SKU D191488. Aladdin Scientific, Shanghai.
2. Müller K, Faeh C, Diederich F. Fluorine in pharmaceuticals: looking beyond intuition. Science. 2007;317(5846):1881-1886. doi:10.1126/science.1131943
3. Gillis EP, Eastman KJ, Hill MD, Donnelly DJ, Meanwell NA. Applications of fluorine in medicinal chemistry. J Med Chem. 2015;58(21):8315-8359. doi:10.1021/acs.jmedchem.5b00258

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.