JAK/STAT Inhibitors

The Janus kinase (JAK) and signal transducer and activator of transcription (STAT) proteins form a critical signaling cascade that conveys extracellular signals across the plasma membrane and into the nucleus, where they modulate gene transcription. This pathway regulates key biological processes, including cell proliferation, differentiation, survival, and host defense. While broadly expressed, JAK/STAT signaling is particularly prominent in immune cells, where it mediates the actions of cytokines, interferons, and growth factors.

Within the nucleus, STAT proteins function as transcription factors by binding to promoter regions of DNA and driving the expression of downstream genes. Dysregulation of this process is implicated in numerous diseases. For example, constitutive activation of STAT3 and STAT5 has been documented in several cancers, leading to persistent signaling activity and uncontrolled gene transcription.

Upstream, JAK proteins act as receptor-associated kinases that phosphorylate and activate STATs following ligand binding to transmembrane receptors. Gain-of-function mutations in JAK genes have been strongly associated with hematologic malignancies, including essential thrombocythemia, myelofibrosis, and various forms of leukemia.

Inhibitors of JAK signaling:

Aladdin catalog	Product name	Purity
A126326 A409220	AZD1480	≥98%, 10mM in DMSO
B345013 B421120	BMS 911543	≥98%, 10mM in DMSO
C127224 M408149	CYT387	≥98%, 10mM in DMSO
F413789 F420902	GLPG-0634	≥98%, 10mM in DMSO
R126338 R409244	INCB018424	≥98%, 10mM in DMSO
J339604 J422387	JAK2 Inhibitor V	≥98%, 10mM in DMSO
P108001 P580488	Piceatannol	≥98%, 10mM in DMSO
T126330 F408078	TG101348	≥98%, 10mM in DMSO
E129454 T408126	Tofacitinib Citrate	≥99%, 10mM in DMSO
A126525 A408508	Tyrphostin AG490	≥98%, 10mM in DMSO
J126663 J422462	JANEX-1	≥98%, 10mM in DMSO

Inhibitors of STAT signaling:

Aladdin catalog	Product name	Purity
C110682 C295384  C423884	Carboplatin	≥98%，≥99.95% metals basis，10mM in Water
D135631  C580352	Corosolic acid	≥98%, 10mM in DMSO
C101973  C101974  C408350	Cryptotanshinone	analytical standard ≥98%，≥98%, 10mM in DMSO
D299451  D117978	Demethoxycurcumin	≥95%，analytical standard ≥98%
E107404  E107403  E409009	Epigallocatechin gallate	≥98%，analytical standard，10mM in DMSO
S171302  S107347  S425032	Sesamin	≥98%，analytical standard， 10mM in DMSO
S125098  S408543	Sorafenib	≥99%, 10mM in DMSO
S111997  S140384  D424040	DL-Sulforaphane	≥95%，≥70%，10mM in DMSO
T109794  T109795  T424804	Tanshinone IIA	analytical standard ≥99%，≥98%，10mM in DMSO

References:

1. Yu H, Pardoll D, Jove R. Nat Rev Cancer. 2009 Nov;9(11):798-809.

2.Berger A, Sexl V, Valent P, et al. Oncotarget. 2014 Oct 30;5(20):9564-76.

3. Vainchenker W, Constantinescu SN. Oncogene. 2013 May 23;32(21):2601-13.

4. Villarino AV, Kanno Y, Ferdinand JR, et al. J Immunol. 2015 Jan 1;194(1):21-7.

Aladdin: https://www.aladdinsci.com/