Carboplatin - Moligand™, ≥99.95% metals basis , CAS No.41575-94-4

CAS: 41575-94-4 Cat. No.: C295384 Molecular Weight: 371.25 EC Number: 255-446-0

GRADE & PURITY Moligand™, ≥99.95% metals basis

Synonyms

AB01273939-01 | EN300-123065 | NSC758182 | NSC-758182 | STL451040 | Tox21_112586_1 | Carboplatinum | DTXCID201476080 | Amikacin impurity I, European Pharmacopoeia (EP) Reference Standard | Pharmakon1600-01502106 | SCHEMBL4964 | Lopac0_000230 | NSC201345 |

Storage

Store at 2-8°C,Protected from light

Shipped In

Wet ice

Overview

Carboplatin is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The development of carboplatin was inspired from the efficacy of its progenitor, Cisplatin (sc-200896), the first of this class of antineoplastic agents. The action of this group of platinum-based compounds is primarily attributed to DNA adduct formation, however, these molecules also bind other biological molecules, including enzymes, which might play a role in their mechanism of action.
An antitumor agent that binds to DNA leading to apoptosis

Product class
hAPIs, Metal based hAPIs

Chemical properties

Chemical formula

C6H12N2O4Pt

Empirical formula

[Pt(NH3)2(cbdc)]

Molecular weight

371.25

Metal

Pt

Theoretical metal content

53

Physical state

powder

Color
Metal purity

white

99.95

Specifications

Synonyms

AB01273939-01 | EN300-123065 | NSC758182 | NSC-758182 | STL451040 | Tox21_112586_1 | Carboplatinum | DTXCID201476080 | Amikacin impurity I, European Pharmacopoeia (EP) Reference Standard | Pharmakon1600-01502106 | SCHEMBL4964 | Lopac0_000230 | NSC201345 |

Specifications & Purity

Moligand™, ≥99.95% metals basis

Biochemical and Physiological Mechanisms

Carboplatin damages DNA by forming intrastrand cross-links with neighboring guanine residues. Tumors acquire resistance to these drugs through the loss of DNA-mismatch repair (MMR) activity and the resultant decrease in the induction of programmed cell de

Legal Information

Product of Umicore

Storage

Store at 2-8°C, Protected from light

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Purity

≥99.95% metals basis

Names and Identifiers

• Pubchem Sid: 504758672
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504758672
• Canonical Smiles: C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]
• IUPAC Name: azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+)
• InChIKey: VSRXQHXAPYXROS-UHFFFAOYSA-N
• INCHI: 1S/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H2;/q;2*-1;+2
• Isomeric SMILES: C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]
• WGK Germany: 3
• RTECS: TP2300000
• Alternate CAS: 41575-94-4
• NSC Number: 201345
• MeSH Entry Terms: Blastocarb;Carboplat;Carboplatin;Carbosin;Carbotec;CBDCA;cis-Diammine(cyclobutanedicarboxylato)platinum II;Ercar;JM 8;JM-8;JM8;Nealorin;Neocarbo;NSC 241240;NSC-241240;NSC241240;Paraplatin;Paraplatine;Platinwas;Ribocarbo
• Molecular Weight: 371.25
• Reaxy-Rn: 25079300
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25079300&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Dicarboxylic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Dicarboxylic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Dicarboxylic acids and derivatives
• Alternative Parents: Organic transition metal salts Carboxylic acids Organic oxides Organic nitrogen compounds Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic homomonocyclic compounds
• Substituents: Dicarboxylic acid or derivatives - Organic transition metal salt - Carboxylic acid - Organic nitrogen compound - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organic salt - Organooxygen compound - Carbonyl group - Aliphatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as dicarboxylic acids and derivatives. These are organic compounds containing exactly two carboxylic acid groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Soluble in water.
• Sensitivity: Light sensitive.
• Melt Point(°C): >275℃
• Molecular Weight: 371.250 g/mol
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 0
• Exact Mass: 371.045 Da
• Monoisotopic Mass: 371.045 Da
• Topological Polar Surface Area: 76.600 Ų
• Heavy Atom Count: 13
• Formal Charge: 0
• Complexity: 177.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 4

XLogP3

References

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2. Yi Xiao, Haomin Yi, Jingzhi Zhu, Suhua Chen, Guofang Wang, Yilong Liao, Yuanyuan Lei, Liyin Chen, Xingcai Zhang, Fangfu Ye.  (2022)  Evaluation of DNA adduct damage using G-quadruplex-based DNAzyme.  Bioactive Materials,      [PMID:36406255] [10.1016/j.bioactmat.2022.10.002]

3. Dong Luo, Wenzhi Chen, Wei Wang, Junlin Chen, Haopeng Xu, Jinyun Chen, Yan Wang.  (2021)  Low-intensity pulsed ultrasound alleviating myelosuppression of Sprague-Dawley rats after combined treating by paclitaxel and carboplatin.  Translational Cancer Research,      [PMID:35116446] [10.21037/tcr-20-3035]

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7. Weibin Luo, Zhengyuan Yang, Shihua Gao, Bin Peng.  (2025)  Construction of Hollow Mesoporous Selenium Loaded With Carboplatin and Clacked With Bevacizumab-Functionalized Albumin Nanoparticles for HER2+ Lung Cancer.  BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY,      [PMID:40620098] [10.1002/bab.70007]

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10. Yong Wang, Jie Pi, Yuzi Zhao, Qingzhen Xie.  (2026)  Hyaluronic Acid-Modified Mesoporous Manganese Dioxide Combined with Carboplatin Synergistically Enhances Ovarian Cancer Therapy.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.jddst.2025.107973]

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