UHPLC Grade — Suitable for Mass Spectrometry (MS)

High-Resolution, Ultra-Clean Solvents for UHPLC-MS and LC-MS/MS Applications

Aladdin Scientific’s UHPLC-MS Grade solvents and reagents are meticulously refined for use in ultra-high-performance liquid chromatography (UHPLC) systems coupled with mass spectrometry (MS) detection. These products are engineered to deliver exceptionally low background noise, high ionization efficiency, and minimal metal or particulate contamination, enabling reliable quantification of analytes at trace or ultra-trace levels.

Key Features

· Ultra-Low UV and MS Background
Spectrally clean at 190–700 nm and background-free in full scan MS modes. Optimized for use in electrospray ionization (ESI) and APCI detection systems.

· Filtered to 0.1–0.2 µm
Prevents clogging in UHPLC columns and minimizes system downtime.

· MS-Compatible Formulations
Free of non-volatile buffers, plasticizers, and metal ions. Designed for use in sensitive MS workflows such as targeted quantitation, untargeted metabolomics, and multi-omics profiling.

· Batch-Tested for UHPLC-MS Suitability
Every lot is tested for critical parameters including UV absorbance, particle count, and MS background noise. Certificate of Analysis (CoA) available with full spectral profile.

Typical Applications

· Ultra-fast and high-resolution separations with UHPLC

· Quantitative and qualitative LC-MS/MS analysis

· Biomarker discovery, drug metabolism studies, and proteomics

· Bioanalytical method development under GLP/GMP settings

· Trace impurity profiling in pharmaceuticals and food safety testing

Available Products

Product Name	Purity	Formats
Acetonitrile, UHPLC-MS Grade	≥99.9%	1L, 2.5L, 4L
Methanol, UHPLC-MS Grade	≥99.9%	1L, 2.5L, 4L
Water, UHPLC-MS Grade	LC-MS quality	1L, 2.5L, 4L
Isopropanol, UHPLC-MS Grade	≥99.9%	1L, 2.5L
Formic Acid, UHPLC-MS Grade	≥99%	25 mL, 100 mL
Ammonium Formate/Acetate (Buffers)	MS-compatible	Powder or solution

Why Choose Aladdin UHPLC-MS Grade?

· Guaranteed compatibility with sub-2 µm columns and high-pressure UHPLC systems

· Minimal ion suppression, improved peak shape, and high reproducibility

· Suitable for both discovery and regulated bioanalytical workflows

UHPLC-MS vs LC-MS vs HPLC Grade Comparison

Attribute	UHPLC-MS Grade	LC-MS Grade	HPLC Grade
Typical Purity	≥99.9%	≥99.99%	≥99.9%
UV Absorbance Control	Ultra-low (190–700 nm)	Low (190–254 nm)	Low (190–254 nm)
MS Background Interference	Virtually none (MS validated)	Very low	Not MS-validated
Filtration Level	≤0.1 µm	≤0.2 µm	≤0.2 µm
Ion Suppression Risk	Minimal	Low	Moderate
Pressure Tolerance	Up to 15,000+ psi	Standard LC pressures	Up to 6,000 psi
Primary Use	High-res UHPLC-MS, targeted MS, multi-omics	General LC-MS workflows, bioanalysis	UV-based HPLC, method development
Documentation	CoA with UV, MS, particle data	CoA with UV & MS specs	CoA with UV trace

Here is the visual comparison table between UHPLC-MS Grade, LC-MS Grade, and HPLC Grade solvents. It highlights key differences in purity, filtration, MS compatibility, and system suitability.

View all UHPLC Grade — Suitable for Mass Spectrometry (MS) Products