Gentamicin - Moligand™, ≥900IU/mg (Microbiological assay of antibiotics, Dried Basis) , Gating inhibitor of TRPA1;Inhibitor of TRPV5, CAS No.1403-66-3, Gating inhibitor of TRPA1;Inhibitor of TRPV5

CAS: 1403-66-3 Cat. No.: G302822 EC Number: 215-765-8

GRADE & PURITY Moligand™, ≥900IU/mg (Microbiological assay of antibiotics, Dried Basis)

Synonyms

Gentamicina | Gentamicine (INN-French) | Lyramycin | STL454325 | Gentamicins | GENTAMYCIN | Gentamicin (TN) | Genoptic S.O.P. | gentamicin | Gentamicinum [INN-Latin] | Gentamycin C1 | 1294497-75-8 | SCHEMBL537630 | AC-13386 | Centicin | HSDB 3087 | Refoba

Storage

Protected from light,Store at -20°C,Argon charged,Desiccated

Shipped In

Ice chest + Ice pads

Overview

Gentamicin is a Aminoglycoside with oral activity, which can inhibit the growth of Gram-positive bacteria and gram-negative bacteria and inhibit many mycoplasma strains in tissue culture. The IC50 value of Gentamicin inhibiting DNase I activity is 0.57 mM.

Specifications

Synonyms

Gentamicina | Gentamicine (INN-French) | Lyramycin | STL454325 | Gentamicins | GENTAMYCIN | Gentamicin (TN) | Genoptic S.O.P. | gentamicin | Gentamicinum [INN-Latin] | Gentamycin C1 | 1294497-75-8 | SCHEMBL537630 | AC-13386 | Centicin | HSDB 3087 | Refoba

Specifications & Purity

Moligand™, ≥900IU/mg (Microbiological assay of antibiotics, Dried Basis)

Storage

Protected from light,Store at -20°C,Argon charged,Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

GATING INHIBITOR, INHIBITOR

Mechanism of action

Gating inhibitor of TRPA1;Inhibitor of TRPV5

Names and Identifiers

• Pubchem Sid: 504750674
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504750674
• Canonical Smiles: CC(C1CCC(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)NC
• IUPAC Name: 2-[4,6-diamino-3-[3-amino-6-[1-(methylamino)ethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol
• InChIKey: CEAZRRDELHUEMR-UHFFFAOYSA-N
• INCHI: 1S/C21H43N5O7/c1-9(25-3)13-6-5-10(22)19(31-13)32-16-11(23)7-12(24)17(14(16)27)33-20-15(28)18(26-4)21(2,29)8-30-20/h9-20,25-29H,5-8,22-24H2,1-4H3
• Isomeric SMILES: CC(C1CCC(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)NC
• Alternate CAS: 1403-66-3
• MeSH Entry Terms: G Myticin;G-Myticin;Garamycin;Gentacycol;Gentamicin;Gentamicin Sulfate;Gentamicin Sulfate (USP);Gentamicins;Gentamycin;Gentamycins;Gentavet;Genticin;GMyticin;Sulfate, Gentamicin
• Reaxy-Rn: 1357063
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1357063&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic oxygen compounds
    • Class Organooxygen compounds
      • Subclass Carbohydrates and carbohydrate conjugates
        • Level5 Aminosaccharides
          • Level6 Aminoglycosides
            • Level7 Aminocyclitol glycosides

• Kingdom: Organic compounds
• Superclass: Organic oxygen compounds
• Class: Organooxygen compounds
• Subclass: Carbohydrates and carbohydrate conjugates
• Intermediate Tree Nodes: Aminosaccharides - Aminoglycosides
• Direct Parent: Aminocyclitol glycosides
• Alternative Parents: 2-deoxystreptamine aminoglycosides O-glycosyl compounds Aminocyclitols and derivatives Cyclohexylamines Cyclohexanols Oxanes Monosaccharides Tertiary alcohols 1,2-aminoalcohols Oxacyclic compounds Dialkylamines Acetals Organopnictogen compounds Monoalkylamines Hydrocarbon derivatives
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: Amino cyclitol glycoside - 2-deoxystreptamine aminoglycoside - Glycosyl compound - O-glycosyl compound - Aminocyclitol or derivatives - Cyclohexanol - Cyclohexylamine - Cyclitol or derivatives - Monosaccharide - Oxane - Tertiary alcohol - Cyclic alcohol - Secondary alcohol - 1,2-aminoalcohol - Secondary amine - Acetal - Organoheterocyclic compound - Secondary aliphatic amine - Oxacycle - Alcohol - Hydrocarbon derivative - Primary aliphatic amine - Organopnictogen compound - Organic nitrogen compound - Amine - Primary amine - Organonitrogen compound - Aliphatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as aminocyclitol glycosides. These are organic compounds containing an amicocyclitol moiety glycosidically linked to a carbohydrate moiety. There are two major classes of aminoglycosides containing a 2-streptamine core. They are called 4,5- and 4,6-disubstituted 2-deoxystreptamines.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

TRPA1 Tclin Transient receptor potential cation channel subfamily A member 1 (1 Activities)

Discover Target: TRPA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPV5 Tchem Transient receptor potential cation channel subfamily V member 5 (0 Activities)

Discover Target: TRPV5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action

Chemical and Physical Properties

• Sensitivity: Moisture sensitive;Heat sensitive;Light sensitive
• Molecular Weight: 477.600 g/mol
• XLogP3: -4.100
• Hydrogen Bond Donor Count: 8
• Hydrogen Bond Acceptor Count: 12
• Rotatable Bond Count: 7
• Exact Mass: 477.316 Da
• Monoisotopic Mass: 477.316 Da
• Topological Polar Surface Area: 200.000 Ų
• Heavy Atom Count: 33
• Formal Charge: 0
• Complexity: 636.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 13
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1