Retinol - BioReagent, ≥97.5%(HPLC), ~3100 U/mg , CAS No.68-26-8

CAS: 68-26-8 Cat. No.: R755730 Molecular Weight: 286.45 Beilstein Registry Number: 403040 EC Number: 200-683-7

GRADE & PURITY BioReagent, ≥97.5%(HPLC), ~3100 U/mg

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

Retinol or vitamin A alcohol is the main circulating form of vitamin A.

Specifications

Specifications & Purity

BioReagent, ≥97.5%(HPLC), ~3100 U/mg

Biochemical and Physiological Mechanisms

It is not biologically active and works as a precursor of active retinoids. Retinol is converted to retinaldehyde and subsequently to retinoic acid.Retinal, retinol and retinoic acid are the aldehyde, alcohol and acid forms of vitamin A. The retinoids ex

Storage

Protected from light, Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

BioReagent

Purity

≥97.5%(HPLC)

Names and Identifiers

• Canonical Smiles: CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CCO)C)C
• IUPAC Name: (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-ol
• InChIKey: FPIPGXGPPPQFEQ-OVSJKPMPSA-N
• INCHI: 1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
• Isomeric SMILES: CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/CO)/C)/C
• WGK Germany: 3
• RTECS: VH6750000
• Molecular Weight: 286.45
• Beilstein: 403040
• Reaxy-Rn: 1913942
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1913942&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Class Prenol lipids
      • Subclass Retinoids

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Class: Prenol lipids
• Subclass: Retinoids
• Intermediate Tree Nodes: Not available
• Direct Parent: Retinoids
• Alternative Parents: Diterpenoids Fatty alcohols Primary alcohols Hydrocarbon derivatives
• Molecular Framework: Aliphatic homomonocyclic compounds
• Substituents: Retinoid skeleton - Diterpenoid - Fatty alcohol - Fatty acyl - Organic oxygen compound - Hydrocarbon derivative - Primary alcohol - Organooxygen compound - Alcohol - Aliphatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as retinoids. These are oxygenated derivatives of 3,7-dimethyl-1-(2,6,6-trimethylcyclohex-1-enyl)nona-1,3,5,7-tetraene and derivatives thereof.
• External Descriptors: Retinoids

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Sensitivity: Hygroscopic
• Refractive Index: 1.641
• Boil Point(°C): 120-125°C
• Melt Point(°C): 61-63°C
• Molecular Weight: 286.500 g/mol
• XLogP3: 5.700
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 5
• Exact Mass: 286.23 Da
• Monoisotopic Mass: 286.23 Da
• Topological Polar Surface Area: 20.200 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 496.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 4
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 4
• Covalently-Bonded Unit Count: 1

References

1. Mingming Chen, Xiaojing Lai, Bihang Su, Xiancai Jiang, Jinhua Xu, Fengfu Fu, Zhenyu Lin, Yongqing Dong.  (2024)  Rapid detection of tebuconazole based on hydrogel SERS chips.  TALANTA,      [PMID:38795591] [10.1016/j.talanta.2024.126309]

2. Liang Qi, Bo-Wen Duan, Hui Wang, Yan-Jun Liu, Han Han, Meng-Meng Han, Lei Xing, Hu-Lin Jiang, Stephen J. Pandol, Ling Li.  (2024)  Reactive Oxygen Species-Responsive Nanoparticles Toward Extracellular Matrix Normalization for Pancreatic Fibrosis Regression.  Advanced Science,      [PMID:38483920] [10.1002/advs.202401254]

3. Li-Shuang Hou, Xiao-Pei Zhai, Yao-Wen Zhang, Jie-Hua Xing, Chen Li, Si-Yuan Zhou, Xiao-Hong Zhu, Bang-Le Zhang.  (2024)  Targeted inhibition of autophagy in hepatic stellate cells by hydroxychloroquine: An effective therapeutic approach for the treatment of liver fibrosis.  LIVER INTERNATIONAL,      [PMID:38606676] [10.1111/liv.15915]

4. Yanjia Guo, Juan Lu, Wenzhuo Wang, Hanyue Jiang, Guangping Ma, Pengfei Han, Li Tian.  (2025)  Molecularly imprinted polymer electrochemiluminescence sensor based on biomass carbon quantum dots from cantaloupe peel for ultrasensitive and specific detection of methylene blue.  JOURNAL OF FOOD COMPOSITION AND ANALYSIS,      [PMID:] [10.1016/j.jfca.2025.108363]

5. Yifan Hong, Xiazhu Zhou, Qi Li, Jing Chen, Yuexin Wei, Siyuan Wang, Xiangqin Zheng, Jie Zhao, Chengjun Yu, Jun Pei, Jie Zhang, Chunlan Long, Lianju Shen, Shengde Wu, Guanghui Wei.  (2023)  Wnt10a downregulation contributes to MEHP-induced disruption of self-renewal and differentiation balance and proliferation inhibition in GC-1 cells: Insights from multiple transcriptomic profiling.  ENVIRONMENTAL POLLUTION,      [PMID:37364752] [10.1016/j.envpol.2023.122091]

6. Ying-zhuo Shen, Zheng Wang, Kangping Ning, Chuanli Ren, Dandan Yang, Xiao-Ya Hu, Qin Xu.  (2023)  Ultrasensitive alkaline phosphatase activity assay based on controllable signal probe production coupled with the cathodic photoelectrochemical analysis.  FOOD CHEMISTRY,      [PMID:37094400] [10.1016/j.foodchem.2023.136177]

7. Lili Zhang, Yutong Hou, Zhanbang Ma, Jinjin Xie, Jiahui Fan, Yaru Jiao, Fangfang Wang, Zongxi Han, Shengwang Liu, Deying Ma.  (2023)  Effect of oral vitamin A supplementation on host immune response to infectious bronchitis virus infection in specific pathogen-free chicken.  POULTRY SCIENCE,      [PMID:37150176] [10.1016/j.psj.2023.102701]

8. Rong Zhang, Wei Jia.  (2022)  Authenticity and traceability of goat milk: Molecular mechanism of β-carotene biotransformation and accessibility.  FOOD CHEMISTRY,      [PMID:35483296] [10.1016/j.foodchem.2022.133073]

9. Xiang Yingying, Song Fei, Jiang Lei, Liu Ze, Tu Yujiao.  (2022)  Novel Fluorescent Nano Carbon Quantum Dots Derived From Lactarius Hatsudake for High Selective Vitamin B12 Detection.  JOURNAL OF AOAC INTERNATIONAL,  105  (5): (1350-1359).  [PMID:35244160] [10.1093/jaoacint/qsac033]

10. Zhang Qianchun, Chen Junyu, Wang Yutong, Xia Guangping, Zheng Yuguo, Wang Xingyi, Wu Yun, Zhang Changbo.  (2021)  Preparation and application of lysozyme aptamer fibre for specific recognition of lysozyme in food samples.  Food Analytical Methods,  14  (7): (1464-1471).  [PMID:] [10.1007/s12161-021-01993-7]

11. Xiuling Ji, Suping Wang, Yiyong Luo, Xiaotian Yuan, Yunlin Wei, Qi Zhang, Kunhao Qin, Yujiao Tu.  (2020)  Green synthesis of weissella-derived fluorescence carbon dots for microbial staining, cell imaging and dual sensing of vitamin B12 and hexavalent chromium.  DYES AND PIGMENTS,      [PMID:] [10.1016/j.dyepig.2020.108818]

12. Siliang Liu, Chunyu Liu, Yu Ren, Shangqi Kuang, Chengcheng Zhou, Hongxing Cai, Zhihai Yao.  (2020)  Fluorescence spectra of nutrients in chicken and skin under baking conditions.  OPTIK,      [PMID:] [10.1016/j.ijleo.2020.164795]

13. Rongrong Xuan, Tingting Wang, Chunyan Hou, Xie Li, Ying Li, Yihui Chen, Yajie Gao, Dan Qiu, Xunwen Xiao, Lihua Zhang, Yukui Zhang.  (2019)  Determination of vitamin A in blood serum based on solid-phase extraction using cetyltrimethyl ammonium bromide-modified attapulgite.  JOURNAL OF SEPARATION SCIENCE,  42  (23): (3521-3527).  [PMID:31560415] [10.1002/jssc.201900778]

14. Fei Yan, Bin Su.  (2016)  Tailoring Molecular Permeability of Nanochannel-Micelle Membranes for Electrochemical Analysis of Antioxidants in Fruit Juices without Sample Treatment.  ANALYTICAL CHEMISTRY,      [PMID:27774789] [10.1021/acs.analchem.6b02823]

15. Fang Liao, Siwei Yang, Xiubing Li, Lijun Yang, Zhihui Xie, Chenshu Hu, Ling He, Xinyuan Kang, Xun Song, Tongyan Ren.  (2014)  Poly(o-phenylenediamine) and benzeneselenol copolymer fluorescent nanorod: An ultra-sensitive fluorescent probe and a fluorescent switch triggered by redox procedure.  SYNTHETIC METALS,      [PMID:] [10.1016/j.synthmet.2014.01.020]

16. Kangyuan Qu, Siyuan Xiong, Caiqian Huang, Xiaoxia Jiang, Lixia Tian, Shiwei Xie.  (2024)  Dietary supplementation of ornithine improved the growth, immune response and acute NH3 stress tolerance of Pacific white shrimp, Penaeus vannamei.  Aquaculture Reports,      [PMID:] [10.1016/j.aqrep.2024.102095]

17. Juanmin Li, Shunsheng Zhao, Lihua Bai, Xiangrong Liu, Li Shang.  (2025)  Ratiometric fluorescence aptasensor for lysozyme based on the controllable excimer formation of perylene probe.  TALANTA,      [PMID:39756257] [10.1016/j.talanta.2025.127521]

18. Shi Ruirui, Wang Chao, Zhu Mingyue, Xie Chen, Cui Wenyu, Zhou Qing.  (2025)  A smartphone-assisted colorimetric paper sensor based on MnO2 nanozymes as oxidase mimetics for rapid evaluation of total antioxidant capacity in foods.  MICROCHIMICA ACTA,  192  (7): (1-10).  [PMID:40500337] [10.1007/s00604-025-07277-9]

19. Li-Shuang Hou, Jin-Yi Zhao, Yan-Qi Zou, Yao-Wen Zhang, Jie-Hua Xing, Wei He, Si-Yuan Zhou, Bang-Le Zhang.  (2025)  Targeted and stimuli-responsive gene/drug synergistic therapeutic system based on pcDNA3.1-Mmp13 and hydroxychloroquine for the effective treatment of liver fibrosis in mice.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.171801]

20. Jianglong Li, Xin Li, Kai Linghu, Niping Yang, Zhengxuan Shao, Jingwen Zhou, Haitong Hou, Weizhu Zeng.  (2026)  Efficient production of retinol in Yarrowia lipolytica via synergistic enzyme and redox engineering.  BIORESOURCE TECHNOLOGY,      [PMID:41558546] [10.1016/j.biortech.2026.134041]

21. He Haisheng, Zhu Wenwei, Miao Han, Wang Shangfeng, Du Zunguo, Zhang Hongxin, Ming Jiang, Shi Ben, Wang Hao, Qi Jianping, Fan Yong, Wu Wei, Zhao Dongyuan, Qin Lun-Xiu, Zhang Fan.  (2026)  Label-free tissue NIR-II autofluorescence imaging for visualization of human liver malignancy.  Nature Biomedical Engineering,      [PMID:41559191] [10.1038/s41551-025-01593-4]

22. Shanshan Guo, Yalin Wang, Binyu Lu, Yu Zhang, David M. Frazer, Bing Zhou.  (2026)  The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis.  Advanced Science,      [PMID:41636743] [10.1002/advs.202516446]

23. Yilong Hu, Yuxin Qi, Jiapeng Mao, Songgela Nuerboli, Yitao Zhang, Kedong Sun, Yuying Yang, Litong Wang, Sijie Wang, Yuting Gu, Yichen Cai, Lei Lin, Jiaxin Huang, Fuchun Yang, Jian You, Lihua Luo.  (2026)  Cellular Adaptive Component-Mediated Targeting of Chylomicron-Mimic Nanoemulsion to Hepatic Stellate Cells for Liver Fibrosis.  ACS Nano,      [PMID:] [10.1021/acsnano.6c00741]

24. Hou Bo, Ma Dewei, Yang Keke, Peng Mingwei, Liu Qinglong, Heng Ziwen, Chen Siyuan, Liu Wei.  (2026)  Co-delivering Retinol and Niacinamide via Liposomes: Enhanced Stability, Efficient Skin Permeation, and Improved Anti-Aging/Skin-Brightening Efficacy.  Journal of Pharmaceutical Innovation,  21  (4): (340).  [PMID:] [10.1007/s12247-026-10594-y]

25. Shen Zhang, Zhuo Wang, Yuyu Guo.  (2026)  Construction of biomass carbon dots and multiple modes for precise determination of VB12.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:] [10.1016/j.saa.2026.127795]