1,2,4,5-Cyclohexanetetracarboxylic Dianhydride - sublimed grade,≥98%(T) , CAS No.2754-41-8

CAS: 2754-41-8 Cat. No.: C153644 Molecular Weight: 224.17 Beilstein Registry Number: 19(4)2233 EC Number: 691-475-9

GRADE & PURITY Sublimed grade, ≥98%(T)

Synonyms

AMY11245 | C2419 | 1,2,4,5-Cyclohexanetetracarboxylic Dianhydride (purified by sublimation) | FT-0659314 | AS-31782 | C2919 | A843128 | 1,2,4,5-CyclohexanetetracarboxylicDianhydride | 1H,3H-Benzo[1,2-c:4,5-c']difuran-1,3,5,7-tetrone, hexahydro- | Hexahydr

Storage

Argon charged,Room temperature

Shipped In

Normal

Specifications

Synonyms

AMY11245 | C2419 | 1, 2, 4, 5-Cyclohexanetetracarboxylic Dianhydride (purified by sublimation) | FT-0659314 | AS-31782 | C2919 | A843128 | 1, 2, 4, 5-CyclohexanetetracarboxylicDianhydride | 1H, 3H-Benzo[1, 2-c:4, 5-c']difuran-1, 3, 5, 7-tetrone, hexahydro- | Hexahydr

Specifications & Purity

sublimed grade, ≥98%(T)

Storage

Argon charged, Room temperature

Shipped In

Normal

Grade

Sublimed grade

Purity

≥98%(T)

Names and Identifiers

• Canonical Smiles: C1C2C(CC3C1C(=O)OC3=O)C(=O)OC2=O
• IUPAC Name: 3a,4,4a,7a,8,8a-hexahydrofuro[3,4-f][2]benzofuran-1,3,5,7-tetrone
• InChIKey: LJMPOXUWPWEILS-UHFFFAOYSA-N
• INCHI: 1S/C10H8O6/c11-7-3-1-4-6(10(14)16-8(4)12)2-5(3)9(13)15-7/h3-6H,1-2H2
• Isomeric SMILES: C1C2C(CC3C1C(=O)OC3=O)C(=O)OC2=O
• Molecular Weight: 224.17
• Beilstein: 19(4)2233
• Reaxy-Rn: 262701
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=262701&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Tetracarboxylic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Tetracarboxylic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Tetracarboxylic acids and derivatives
• Alternative Parents: Oxolanes Carboxylic acid anhydrides Lactones Oxacyclic compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic heteropolycyclic compounds
• Substituents: Tetracarboxylic acid or derivatives - Oxolane - Carboxylic acid anhydride - Lactone - Oxacycle - Organoheterocyclic compound - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Aliphatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as tetracarboxylic acids and derivatives. These are carboxylic acids containing exactly four carboxyl groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Solubility in Acetone:almost transparency
• Sensitivity: Moisture sensitive
• Flash Point(°C): 238.6℃
• Boil Point(°C): 517.5±50.0 °C
• Melt Point(°C): 240°C(lit.)
• Molecular Weight: 224.170 g/mol
• XLogP3: -0.500
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 0
• Exact Mass: 224.032 Da
• Monoisotopic Mass: 224.032 Da
• Topological Polar Surface Area: 86.700 Ų
• Heavy Atom Count: 16
• Formal Charge: 0
• Complexity: 349.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 4
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Min Zhong, Peiqin Liang, Zhenzhen Feng, Xin Yang, Guang Li, Rui Sun, Lijuan He, Jinxiu Tan, Yangpengcheng Xiao, Zhiqiang Yu, Muhua Yi, Xuefeng Wang.  (2023)  A nanocomposite competent to overcome cascade drug resistance in ovarian cancer via mitochondria dysfunction and NO gas synergistic therapy.  Asian Journal of Pharmaceutical Sciences,      [PMID:38161785] [10.1016/j.ajps.2023.100872]

2. Xiaohong Li, Minyan Wang, Nafeesa Mushtaq, Guofei Chen, Guohua Li, Xingzhong Fang, Anjiang Zhang.  (2022)  Colorless polyimide films with low birefringence and retardation: Synthesis and characterization.  POLYMER,      [PMID:] [10.1016/j.polymer.2022.125579]

3. Lei Cao, Huixiang Tian, Man Fang, Zhe Xu, Dongsheng Tang, Juan Chen, Jiye Yin, Haihua Xiao, Kun Shang, Hongbin Han, Xiangping Li.  (2022)  Activating cGAS-STING pathway with ROS-responsive nanoparticles delivering a hybrid prodrug for enhanced chemo-immunotherapy.  BIOMATERIALS,      [PMID:36306685] [10.1016/j.biomaterials.2022.121856]

4. Zhang Hanchen, Montesdeoca Nicolás, Tang Dongsheng, Liang Ganghao, Cui Minhui, Xu Chun, Servos Lisa-Marie, Bing Tiejun, Papadopoulos Zisis, Shen Meifang, Xiao Haihua, Yu Yingjie, Karges Johannes.  (2024)  Tumor-targeted glutathione oxidation catalysis with ruthenium nanoreactors against hypoxic osteosarcoma.  Nature Communications,  15  (1): (1-23).  [PMID:39477929] [10.1038/s41467-024-53646-y]

5. Wentao Chen, Ke Zhang, Shuai Wang, Siyu Wang, Chunhai Chen, Xiaogang Zhao, Hongwei Zhou, Daming Wang.  (2025)  Construction of an interphase with heat and solvent resistance by a waterborne self-crosslinking polyamide-imide sizing agent to enhance the interfacial and mechanical performance of CF/PEEK composites.  COMPOSITES PART B-ENGINEERING,      [PMID:] [10.1016/j.compositesb.2025.113330]

6. Qiang Li, Lingxuan Yang, Qi Zhou, Erpeng Wang, Yuhao Lin, Hao Du, Zhiheng Li, Limin Jin, Chuncheng Chen, Qi Wang.  (2026)  Sustained hydroxyl radical generation via a robust metal-free polyimide photocatalyst for water remediation.  APPLIED CATALYSIS B-ENVIRONMENTAL,      [PMID:] [10.1016/j.apcatb.2026.126390]

7. Chuanjia Jiao, Jiayan Li, Caixia Wan, Jiawei Zou, Shifang Luan.  (2026)  Synergistic Regulation of Dual Monomers for Constructing High Bandgap and High Polarity Polyimide with High-Temperature Capacitive Energy Storage Performance.  Journal of Materials Chemistry A,      [PMID:] [10.1039/D5TA09731B]

8. Yunhao Gao, Feiya Yang, Lu Yin, Wenkuan Wang, Kai Wang, Hanchen Zhang, Zhen Zhang, Dong Chen, Kehao Pan, Wen Liu, Bin Jia, Chun Xu, Zheng Cao, Aolong Chen, Delong Pei, Haihua Xiao, Zhiqiang Shao, Nianzeng Xing.  (2026)  A Redox-Responsive Selenium-Containing Nanomedicine Enables Dual Antioxidant System Inhibition to Overcome Platinum Resistance and Enhance Immunotherapy in Bladder Cancer.  ACS Nano,      [PMID:] [10.1021/acsnano.5c21831]