1-Deoxynojirimycin - Moligand™,≥98% , CAS No.19130-96-2

CAS: 19130-96-2 Cat. No.: D1507796 Formula: C₆H₁₃NO₄ Peso molecolare: 163.17 Numero EC: 606-239-2

GRADE & PURITY Moligand™, ≥98%

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Panoramica

Deoxynojirimycin is a Maltase-glucoamylase (α-glucosidase I and II) inhibitor. Interferes with N-linked glycosylation. Reported to inhibit trimming of oligosaccharides upon treatment of secretory glycoprotein IgD- and IgM-producing cells. Reported to inhibit secretion of IgD. Deoxynojirimycin is an inhibitor of β-glucosidase and Maltase-glucoamylase.
An inhibitor of α-glucosidase I and II

Specifications

Specifiche e purezza

Moligand™,≥98%

Meccanismi biochimici e fisiologici

Potent α-glycosidase inhibitor (IC 50 = 30 nM). Antihyperglycemic agent. Downregulates SGLT1, Na + /K + -ATP and GLUT2 expression. Decreases MCP-1 and TNF-α levels. Shows antidiabetic, antiviral, antiobesity and anti-inflammatory effects in vivo. Orally a

Condizioni di conservazione di stoccaggio

Store at -20°C,Argon charged

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purezza

≥98%

Nomi e identificatori

• Sorrisi canonici: C1C(C(C(C(N1)CO)O)O)O
• IUPAC Name: (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol
• InChIKey: LXBIFEVIBLOUGU-JGWLITMVSA-N
• INCHI: 1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
• Isomeri SMILES: C1[C@@H]([C@H]([C@@H]([C@H](N1)CO)O)O)O
• Peso molecolare: 163.17
• Reaxy-Rn: 13313614
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=13313614&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Piperidines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Piperidines
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Piperidines
• Alternative Parents: Secondary alcohols 1,2-aminoalcohols Polyols Dialkylamines Azacyclic compounds Primary alcohols Organopnictogen compounds Hydrocarbon derivatives
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: Piperidine - 1,2-aminoalcohol - Secondary alcohol - Secondary aliphatic amine - Polyol - Secondary amine - Azacycle - Primary alcohol - Alcohol - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Organopnictogen compound - Amine - Hydrocarbon derivative - Aliphatic heteromonocyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as piperidines. These are compounds containing a piperidine ring, which is a saturated aliphatic six-member ring with one nitrogen atom and five carbon atoms.
• External Descriptors: 2-(hydroxymethyl)piperidine-3,4,5-triol

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Proprietà chimiche e fisiche

• Solubilità: Soluble in water (25 mg/ml), and methanol., Soluble in water (25 mg/ml), and methanol.
• Sensibilità: Air sensitive
• Peso molecolare: 163.170 g/mol
• XLogP3: -2.300
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 163.084 Da
• Monoisotopic Mass: 163.084 Da
• Topological Polar Surface Area: 93.000 Ų
• Heavy Atom Count: 11
• Formal Charge: 0
• Complexity: 132.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 4
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Riferimenti

1. Nan Wu, Wenjing Zhang, Sunyue He, Lusi Lu, Yiming Liu, Shuainan Liu, Lei Lei, Shuiya Sun, Yuchen Zhao, Chunyi Xu, Xihua Lin, Jiaqiang Zhou.  (2025)  Ramulus Mori (Sangzhi) Alkaloids Enhance Pancreatic β-Cell Maturation and Function by Targeting the CD81/Endoplasmic Reticulum Stress Pathway.  PHYTOMEDICINE,      [PMID:40819639] [10.1016/j.phymed.2025.157150]

2. Xinlin Chen, Ying Wu, Yucheng Gu, Jianguang Luo, Lingyi Kong.  (2022)  Efficient discovery of potent α-glucosidase inhibitors from Paeoniae lactiflora using enzyme–MOF nanocomposites and competitive indicators.  Food & Function,  14  (1): (171-180).  [PMID:36477546] [10.1039/D2FO02783F]

3. Yang Liu, Xue Zhou, Dan Zhou, Yongxing Jian, Jingfu Jia, Fahuan Ge.  (2022)  Isolation of Chalcomoracin as a Potential α-Glycosidase Inhibitor from Mulberry Leaves and Its Binding Mechanism.  MOLECULES,  27  (18): (5742).  [PMID:36144478] [10.3390/molecules27185742]

4. Yanfang Yu, Yuhuan Chen, Xuping Shi, Chuan Ye, Junwen Wang, Jinzhi Huang, Bing Zhang, Zeyuan Deng.  (2022)  Hepatoprotective effects of different mulberry leaf extracts against acute liver injury in rats by alleviating oxidative stress and inflammatory response.  Food & Function,  13  (16): (8593-8604).  [PMID:35894215] [10.1039/D2FO00282E]

5. Yanfang Yu, Hongyan Li, Bing Zhang, Junwen Wang, Xuping Shi, Jinzhi Huang, Jianyuan Yang, Yanfei Zhang, Zeyuan Deng.  (2018)  Nutritional and functional components of mulberry leaves from different varieties: Evaluation of their potential as food materials.  INTERNATIONAL JOURNAL OF FOOD PROPERTIES,      [PMID:] [10.1080/10942912.2018.1489833]

6. Zongcheng Zhang, Yu Wang, Feifei Wang, Yushu Li, Li-Jun Ma, Jian Sun.  (2026)  Fluorescent iron-doped polymer dot nanozyme-based cascade reaction for α-glucosidase activity and inhibitor detection.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:] [10.1016/j.saa.2026.128678]