10-DEBC cloridrato - Moligand™, ≥99% , Inhibitor of Pim-1 proto-oncogene; serine/threonine kinase, CAS No.201788-90-1, Inhibitor of Pim-1 proto-oncogene; serine/threonine kinase

CAS: 201788-90-1 Cat. No.: D335507 Formula: C₂₀H₂₅ClN₂O・HCl Peso molecolare: 381.34 PubChem CID: 16760284

GRADE & PURITY Moligand™, ≥99%

Synonyms

aktX | 10-[4'-(n,n-diethylamino)butyl]-2-chlorophenoxazine hydrochloride | 10-DEBCHYDROCHLORIDE | 10-DEBC HYDROCHLORIDE | Akt Inhibitor-X | Akt Inhibitor X | CCG 206734 | 10-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine, HCl | 4-(2-chlorophenoxazin-10-yl

Storage

Conservare a 2-8°C, essiccato

Shipped In

Ghiaccio umido

Panoramica

Inibitore selettivo di Akt/PKB. Inibisce la fosforilazione e l'attivazione di Akt stimolate dall'IGF-1 (inibizione completa a 2,5 μM), sopprimendo l'attivazione a valle di mTOR, p70 S6 chinasi e proteina ribosomiale S6. Non mostra alcuna attività nei confronti di PDK1, SGK1 o PI 3-kin

Specifications

Sinonimi

aktX | 10-[4'-(n,n-diethylamino)butyl]-2-chlorophenoxazine hydrochloride | 10-DEBCHYDROCHLORIDE | 10-DEBC HYDROCHLORIDE | Akt Inhibitor-X | Akt Inhibitor X | CCG 206734 | 10-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine, HCl | 4-(2-chlorophenoxazin-10-yl

Specifiche e purezza

Moligand™, ≥99%

Condizioni di conservazione di stoccaggio

Conservare a 2-8°C, essiccato

Spedito in

Ghiaccio umido

Grado

Moligand™

Tipo di azione

INHIBITOR

Meccanismo d'azione

Inhibitor of Pim-1 proto-oncogene; serine/threonine kinase

Purezza

≥99%

Nomi e identificatori

• Sorrisi canonici: CCN(CC)CCCCN1C2=CC=CC=C2OC3=C1C=C(C=C3)Cl.Cl
• IUPAC Name: 4-(2-chlorophenoxazin-10-yl)-N,N-diethylbutan-1-amine;hydrochloride
• InChIKey: SVKSJUIYYCQZEC-UHFFFAOYSA-N
• INCHI: 1S/C20H25ClN2O.ClH/c1-3-22(4-2)13-7-8-14-23-17-9-5-6-10-19(17)24-20-12-11-16(21)15-18(20)23;/h5-6,9-12,15H,3-4,7-8,13-14H2,1-2H3;1H
• Isomeri SMILES: CCN(CC)CCCCN1C2=CC=CC=C2OC3=C1C=C(C=C3)Cl.Cl
• PubChem CID: 16760284
• Peso molecolare: 381.34

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Benzoxazines
      • Subclass Phenoxazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Benzoxazines
• Subclass: Phenoxazines
• Intermediate Tree Nodes: Not available
• Direct Parent: N-substituted phenoxazines
• Alternative Parents: Alkyldiarylamines Diarylethers Benzenoids Aryl chlorides Quaternary ammonium salts Trialkylamines Oxacyclic compounds Azacyclic compounds Organochlorides Organic chloride salts Hydrocarbon derivatives Organic cations
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: N-substituted phenoxazine - Alkyldiarylamine - Diaryl ether - Tertiary aliphatic/aromatic amine - Aryl chloride - Aryl halide - Benzenoid - Quaternary ammonium salt - Tertiary aliphatic amine - Tertiary amine - Oxacycle - Azacycle - Ether - Organic salt - Hydrocarbon derivative - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Organic nitrogen compound - Organic chloride salt - Amine - Organic cation - Aromatic heteropolycyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as n-substituted phenoxazines. These are phenoxyazines where the nitrogen atom is linked to an atom other than the hydrogen atom.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Obiettivi associati (umani)

PIM1 Tchem Serine/threonine-protein kinase pim-1 (1 Activities)

Discover Target: PIM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Proprietà chimiche e fisiche

• Solubilità: Soluble in water (1 mg/ml), DMSO (100 mM), and methanol.
• Indice di rifrazione: n20D1.57 (Predicted)
• Peso molecolare: 381.300 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 7
• Exact Mass: 380.142 Da
• Monoisotopic Mass: 380.142 Da
• Topological Polar Surface Area: 15.700 Ų
• Heavy Atom Count: 25
• Formal Charge: 0
• Complexity: 377.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3