2,6-Dihydroxybenzoic acid - 10mM in DMSO , CAS No.303-07-1

CAS: 303-07-1 Cat. No.: D423129 Molecular Weight: 154.12 Beilstein Registry Number: 2209755 EC Number: 206-134-8
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GRADE & PURITY 10mM in DMSO
Synonyms
2,6-dihydroxy benzoic acid | 2,6-Dihydroxybenzoic acid, Vetec(TM) reagent grade, 98% | AC8078 | NSC 49172 | ??resorcylic acid | 2,6-Dihydroxybenzoesaeure | 4-10-00-01456 (Beilstein Handbook Reference) | 2-Carboxyresorcinol | MFCD00002462 | 2,6-Dihydroxybe
Storage
Protected from light,Store at -80°C
Shipped In
Dry ice packs + Cold packs
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Size
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Price
Qty
1ml
D423129-1ml
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Why this grade

10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Protected from light,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 19 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
2, 6-dihydroxy benzoic acid | 2, 6-Dihydroxybenzoic acid, Vetec(TM) reagent grade, 98% | AC8078 | NSC 49172 | ??resorcylic acid | 2, 6-Dihydroxybenzoesaeure | 4-10-00-01456 (Beilstein Handbook Reference) | 2-Carboxyresorcinol | MFCD00002462 | 2, 6-Dihydroxybe
Specifications & Purity
10mM in DMSO
Storage
Protected from light, Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Names and Identifiers
Canonical SmilesC1=CC(=C(C(=C1)O)C(=O)O)O
IUPAC Name2,6-dihydroxybenzoic acid
InChIKeyAKEUNCKRJATALU-UHFFFAOYSA-N
INCHI1S/C7H6O4/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3,8-9H,(H,10,11)
Isomeric SMILES C1=CC(=C(C(=C1)O)C(=O)O)O
WGK Germany 3
RTECS DG8578000
Alternate CAS 303-07-1
NSC Number 49172
MeSH Entry Terms 2,6-dihydroxybenzoic acid;gamma-resorcylic acid
Molecular Weight 154.12
Beilstein 2209755
Reaxy-Rn 2209755
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2209755&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

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✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

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Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassBenzenoids
ClassBenzene and substituted derivatives
SubclassBenzoic acids and derivatives
Intermediate Tree Nodes Hydroxybenzoic acid derivatives - Salicylic acid and derivatives
Direct ParentSalicylic acids
Alternative Parents Benzoic acids  Resorcinols  Benzoyl derivatives  1-hydroxy-4-unsubstituted benzenoids  1-hydroxy-2-unsubstituted benzenoids  Vinylogous acids  Monocarboxylic acids and derivatives  Carboxylic acids  Organooxygen compounds  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAromatic homomonocyclic compounds
Substituents Salicylic acid - Benzoic acid - Benzoyl - Resorcinol - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Vinylogous acid - Carboxylic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Organic oxygen compound - Organic oxide - Organooxygen compound - Hydrocarbon derivative - Aromatic homomonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as salicylic acids. These are ortho-hydroxylated benzoic acids.
External Descriptors dihydroxybenzoic acid
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
CA2 Tclin Carbonic anhydrase II (17698 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALOX5 Tclin Arachidonate 5-lipoxygenase (6568 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TYR Tclin Tyrosinase (717 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA1 Tclin Carbonic anhydrase I (13240 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA14 Tclin Carbonic anhydrase XIV (1305 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MMP3 Tchem Matrix metalloproteinase 3 (3433 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MMP8 Tchem Matrix metalloproteinase 8 (1942 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA12 Tclin Carbonic anhydrase XII (6231 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA9 Tclin Carbonic anhydrase IX (8255 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MMP1 Tchem Matrix metalloproteinase-1 (7046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hydroxyapatite (165 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Ca7 Carbonic anhydrase VII (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nos2 Nitric oxide synthase, inducible (3573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mmp2 Matrix metalloproteinase-2 (12 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
lef Anthrax lethal factor (7585 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
SensitivityLight sensitive.
Melt Point(°C)160-165°C
Molecular Weight154.120 g/mol
XLogP32.200
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass154.027 Da
Monoisotopic Mass154.027 Da
Topological Polar Surface Area77.800 Ų
Heavy Atom Count11
Formal Charge0
Complexity147.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
References
1. Xiu-Ni Hua, Xia Pan, Yang Zhu, Zhuoer Cai, Qi Song, Yaozhenhui Li, Wenbin Feng, Xin Chen, Hui Zhang, Baiwang Sun.  (2022)  Novel pharmaceutical salts of cephalexin with organic counterions: structural analysis and properties.  RSC Advances,  12  (54): (34843-34850).  [PMID:36540208] [10.1039/D2RA05565A]
2. Yujiang Xie, Genpei Shi, Jie Sun, Si Li, Wei Gao, Yimin Hu, Chang Zu, Weiwei Tang, Junbo Gong.  (2022)  Computational Screening and Experimental Validation on Multicomponent Crystals of a New Class of Janus Kinase (JAK) Inhibitor Drug with Improved Solubility.  Crystals,  12  (12): (1722).  [PMID:] [10.3390/cryst12121722]
3. Guojia Yu, Xinjian Chen, Lichao He, Xiangrong Li, Zhiyong Zhou, Zhongqi Ren.  (2021)  Study on the solubilization of telmisartan by forming cocrystals with aromatic carboxylic acids.  CRYSTENGCOMM,  23  (27): (4871-4878).  [PMID:] [10.1039/D1CE00551K]
4. Deying Meng, Huangmei Zhou, Jianhua Xu, Sanjun Zhang.  (2021)  Studies on the interaction of salicylic acid and its monohydroxy substituted derivatives with bovine serum albumin.  CHEMICAL PHYSICS,      [PMID:] [10.1016/j.chemphys.2021.111182]
5. Ma Mingxuan, Du Yingxiang, Zhang Liu, Gan Jie, Yang Jiangxia.  (2020)  β-Cyclodextrin covalent organic framework–modified organic polymer monolith as a stationary phase for combined hydrophilic and hydrophobic aqueous capillary electrochromatographic separation of small molecules.  MICROCHIMICA ACTA,  187  (7): (1-11).  [PMID:32533434] [10.1007/s00604-020-04360-1]
6. Mingfang Zhu, Hongqing Ye, Mushen Lai, Jianshan Ye, Rui Li, Wenhao Zhang, Huanru Liang, Rongkun Zhu, Huajun Fan, Shi Chen.  (2019)  The gold nanoparticle sensitized pRGO-MWCNTs grid modified carbon fiber microelectrode as an efficient sensor system for simultaneous detection of three dihydroxybenzoic acid isomers.  ELECTROCHIMICA ACTA,      [PMID:] [10.1016/j.electacta.2019.134765]
7. Qiqin Wang, Huihui Wu, Kun Peng, Hanying Jin, Huikai Shao, Yuqiang Wang, Jacques Crommen, Zhengjin Jiang.  (2017)  Hydrophilic polymeric monoliths containing choline phosphate for separation science applications.  ANALYTICA CHIMICA ACTA,      [PMID:29254571] [10.1016/j.aca.2017.11.032]
8. Yuyan Wang, Yanxin Chen, Peipei Zhu, Ying Bao, Chuang Xie, Junbo Gong, Xiaobin Jiang, Baohong Hou, Wei Chen.  (2017)  Measurement and Correlation of the Solubility of 2,6-Dihydroxybenzoic Acid in Alcohols and Binary Solvents.  JOURNAL OF CHEMICAL AND ENGINEERING DATA,      [PMID:] [10.1021/acs.jced.6b00957]
9. Guangxin Yuan, Yongbo Peng, Zhenghua Liu, Jieya Hong, Yao Xiao, Jialiang Guo, Norman W. Smith, Jacques Crommen, Zhengjin Jiang.  (2013)  A facile and efficient strategy to enhance hydrophilicity of zwitterionic sulfoalkylbetaine type monoliths.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:23796416] [10.1016/j.chroma.2013.05.063]
10. Yuanqing Fu, Shan Hong, Duo Li, Songbai Liu.  (2013)  Novel Chemical Synthesis of Ginkgolic Acid (13:0) and Evaluation of Its Tyrosinase Inhibitory Activity.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:23701207] [10.1021/jf4012642]
11. Yanan Mao, Kairu Wang, Mengge Liu, Chenyue Lu, Xinghua Zhao, Xin He.  (2024)  Enhancing the Bioavailability of a Novel Enrofloxacin Salt by Inhibiting Precipitation via a Crystallization Inhibitor.  CRYSTAL GROWTH & DESIGN,      [PMID:] [10.1021/acs.cgd.4c00021]
12. Liang Lai, Mengyao Zhang, Tong Li, Jiahuan Qu, Dongsheng Xu, Pei Yu, Zhengjin Jiang.  (2024)  Preparation and evaluation of a piperidinium-sulfonate based zwitterionic monolith for HILIC separation.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:38598890] [10.1016/j.chroma.2024.464864]
13. Jianhong Liu, Yujie Han, Xin He, Xinghua Zhao.  (2025)  Piperine cocrystals ameliorates type 2 diabetes by regulating glycolipid metabolism and reshaping gut microbiota in mice.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.jddst.2025.107356]
14. Binfen Zhao, Yuxuan Wang, Jiutong Ma, Qiong Jia.  (2022)  Design of a hydrophilic mercaptosuccinic acid-functionalized β-cyclodextrin polymer via host–guest interaction: toward highly efficient glycopeptide enrichment.  ANALYST,  147  (20): (4553-4561).  [PMID:36102749] [10.1039/D2AN01358D]
15. Jincai Wang, Jialiang Guo, Haowen Chen, Xiaoling Huang, Govert W. Somsen, Fenyun Song, Zhengjin Jiang.  (2020)  A single-step preparation of carbohydrate functionalized monoliths for separation and trapping of polar compounds.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:32822998] [10.1016/j.chroma.2020.461481]
16. Chusheng Liu, Weijia Chen, Guangxin Yuan, Yao Xiao, Jacques Crommen, Shihai Xu, Zhengjin Jiang.  (2014)  Influence of the crosslinker type on the chromatographic properties of hydrophilic sulfoalkylbetaine-type monolithic columns.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:25464999] [10.1016/j.chroma.2014.11.007]
17. Liang Lai, Hongying Lan, Hui Huang, Tong Li, Kesara Ar-sanork, Jia-Huan Qu, Dongsheng Xu, Zhengjin Jiang.  (2025)  Fabrication and evaluation of a dual-zwitterionic functionalized hydrophilic monolith for chromatographic separation.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:40199033] [10.1016/j.chroma.2025.465917]
18. Qiaoxuan Zhang, Ning Deng, Yingying Dai, Min Zhan, Huihui Wu, Jialin Zeng, Qiqin Wang, Zhengjin Jiang.  (2024)  Zwitterionic sulfobetaine-based hypercrosslinked hydrophilic materials for bioanalysis.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.153018]
19. Yiming Sun, Chenying Zhou, Shuang Meng, Shuang Zhong, Yang Liu, Chuanshu He, Peng Zhou, Bo Lai.  (2025)  Boron-Doped Carbon Material Modulated Highly Reactive Near-Free Fe(III) for Accelerated and Long-Lasting Fenton Oxidation with Hydrogen Peroxide as a Green Electron Donor.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,      [PMID:41108264] [10.1021/acs.est.5c10132]
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