2′-Hydroxychalcone - Moligand™, 10 mM in DMSO , CAS No.1214-47-7

CAS: 1214-47-7 Cat. No.: H1500431 Molecular Weight: 224.25 Beilstein Registry Number: 976324 EC Number: 214-928-0

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

2′-Hydroxychalcone is a hydroxyl derivative of chalcones with anticancer activities. 2'-Hydroxychalcone inhibits NF-κB pathway and induces autophagy and apoptosis in breast cancer cells. 2′-Hydroxychalcone shows a better antifungal activity against the complex Paracoccidioides spp.

Specifications

Specifications & Purity

Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Names and Identifiers

• Isomeric SMILES: C1=CC=C(C=C1)/C=C/C(=O)C2=CC=CC=C2O
• WGK Germany: 3
• RTECS: UD5579400
• Molecular Weight: 224.25
• Beilstein: 976324
• Reaxy-Rn: 976324
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=976324&ln=

Chemical and Physical Properties

• Melt Point(°C): 87 °C

References

1. Changjiao Shang, Yajie Zhang, Chaofan Sun, Lingling Wang.  (2022)  Tactfully improve the antioxidant activity of 2′-hydroxychalcone with the strategy of substituent, solvent and intramolecular hydrogen bond effects.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2022.119748]

2. Jiamei Fu, Mengqiu Quan, Haiquan Sun, Junyi Zhou, Qingyi Xie, Minghui Cui, Xiaolin Wang, Fenglong Li, Jin Zhu, Jing Chen.  (2025)  Optimized Bio-Based Polyurethane Structure for Enhanced Durability and Biocompatibility in Artificial Ligaments.  Advanced Healthcare Materials,      [PMID:41097825] [10.1002/adhm.202503953]