20-COOH-LTB4 - ≥97%, 100 μg/ml in etanolo , CAS No.80434-82-8

CAS: 80434-82-8 Cat. No.: C353436 Formula: C₂₀H₃₀O₆ Peso molecolare: 366.45 Numero EC: 632-880-2 PubChem CID: 5280877

GRADE & PURITY ≥97%, 100 μg/ml in ethanol

Synonyms

BML1-E06 | HY-113483 | (S-(R*,S*-(E,Z,E,Z)))-5,12-dihydroxy-6,8,10,14-Eicosatetraenedioate | 20-carboxyleukotriene B4 | 20-Carboxy-leukotriene B4 | 20-Carboxy-leukotriene- B4 | (S-(R*,S*-(E,Z,E,Z)))-5,12-dihydroxy-6,8,10,14-Eicosatetraenedioic acid | C059

Storage

Conservare a -20°C

Shipped In

Cassetta del ghiaccio + cuscini per il ghiaccio

Panoramica

20-COOH-LTB|4|è un metabolita ω-ossidato del leucotriene B|4|. È stato dimostrato che i leucotrieni sono potenti mediatori lipidici eicosanoidi derivati dall'acido arachidonico rilasciato dalle fosfolipasi. Questi composti sono stati segnalati come coinvolti nell'infiammazione e in numerose funzioni biologiche omeostatiche. Negli epatociti di ratto, il 20-COOH-LTB|4|è noto per essere un substrato per le vie di β-ossidazione presenti nei perossisomi e nei mitocondri.

Specifications

Sinonimi

BML1-E06 | HY-113483 | (S-(R*,S*-(E,Z,E,Z)))-5,12-dihydroxy-6,8,10,14-Eicosatetraenedioate | 20-carboxyleukotriene B4 | 20-Carboxy-leukotriene B4 | 20-Carboxy-leukotriene- B4 | (S-(R*,S*-(E,Z,E,Z)))-5,12-dihydroxy-6,8,10,14-Eicosatetraenedioic acid | C059

Specifiche e purezza

≥97%, 100 μg/ml in etanolo

Condizioni di conservazione di stoccaggio

Conservare a -20°C

Spedito in

Cassetta del ghiaccio + cuscini per il ghiaccio

Tipo di azione

INHIBITOR

Purezza

≥97%

Proprietà del prodotto

• pKa: pKa: 4.66

Nomi e identificatori

• Sorrisi canonici: C(CCC(=O)O)CC=CCC(C=CC=CC=CC(CCCC(=O)O)O)O
• IUPAC Name: (5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,14-tetraenedioic acid
• InChIKey: SXWGPVJGNOLNHT-VFLUTPEKSA-N
• INCHI: 1S/C20H30O6/c21-17(11-6-2-1-3-9-15-19(23)24)12-7-4-5-8-13-18(22)14-10-16-20(25)26/h2,4-8,12-13,17-18,21-22H,1,3,9-11,14-16H2,(H,23,24)(H,25,26)/b5-4+,6-2-,12-7+,13-8-/t17-,18-/m1/s1
• Isomeri SMILES: C(CCC(=O)O)C/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O
• WGK Germania: 3
• PubChem CID: 5280877
• Peso molecolare: 366.45

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Classe Fatty Acyls
      • Subclass Fatty acids and conjugates

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Classe: Fatty Acyls
• Subclass: Fatty acids and conjugates
• Intermediate Tree Nodes: Not available
• Direct Parent: Long-chain fatty acids
• Alternative Parents: Hydroxy fatty acids Unsaturated fatty acids Dicarboxylic acids and derivatives Secondary alcohols Carboxylic acids Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Long-chain fatty acid - Hydroxy fatty acid - Unsaturated fatty acid - Dicarboxylic acid or derivatives - Secondary alcohol - Carboxylic acid - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Alcohol - Aliphatic acyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as long-chain fatty acids. These are fatty acids with an aliphatic tail that contains between 13 and 21 carbon atoms.
• External Descriptors: Leukotrienes

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Meccanismi d'azione

Proprietà chimiche e fisiche

• Solubilità: Soluble in water, ethanol, DMF, DMSO, and PBS pH 7.2.
• Indice di rifrazione: n20D1.55
• Punto di infiammabilità (°F): 57.2 °F
• Punto di infiammabilità (°C): 14 °C
• Punto di ebollizione (°C): 78° C
• Peso molecolare: 366.400 g/mol
• XLogP3: 2.400
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 15
• Exact Mass: 366.204 Da
• Monoisotopic Mass: 366.204 Da
• Topological Polar Surface Area: 115.000 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 504.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 4
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 4
• Covalently-Bonded Unit Count: 1

Domande frequenti

What is the purity of this product?

This product is supplied at ≥97% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 80434-82-8, the molecular formula is C20H30O6, and the molecular weight is 366.45 g/mol. InChIKey SXWGPVJGNOLNHT-VFLUTPEKSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.