7-Cl-O-Nec1 - Moligand™, 10mM in DMSO , Inhibitor of receptor interacting serine/threonine kinase 1, CAS No.852391-15-2, Inhibitor of receptor interacting serine/threonine kinase 1

CAS: 852391-15-2 Cat. No.: N409256 Formula: C₁₃H₁₂ClN₃O₂ Peso molecolare: 277.7

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

7-Cl-O-Nec1, Necrostatin-1 stable, Necrostatin 1S | 2,​4-​Imidazolidinedione, 5-​[(7-​chloro-​1H-​indol-​3-​yl)​methyl]​-​3-​methyl- | 5-[(7-Chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione | Nec-1s | Necrostatin 2 racemate | Necrostatin 1s

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

Information

Necrostatin 2 racemate (Nec-1s) Necrostatin 2 racemate (Nec-1s, 7-Cl-O-Nec1, Necrostatin-1 stable, Necrostatin 1S) is a stable variant of Necrostatin-1. It is a more specific RIPK1 inhibitor lacking the IDO-targeting effect, with >1000-fold more selecti
In vitro

Nec-1s is a potent inhibitor of RIPK1 and cellular necroptosis while lacking IDO inhibitory activity.

In vivo

Nec-1s is effective in reducing brain injuries. It is a superior inhibitor suitable for use in vivo lacking a paradoxical sensitizing effect in TNF-induced lethality. Nec-1s possesses several advantageous pharmacokinetic and pharmacodynamic characteristics in comparison to Nec-1. Safety profile of Nec-1s is also superior to that of Nec-1 for reduced in vivo and in vitro toxicity.
Cell Data

cell lines：Cell lines:

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Sinonimi

7-Cl-O-Nec1, Necrostatin-1 stable, Necrostatin 1S | 2,​4-​Imidazolidinedione, 5-​[(7-​chloro-​1H-​indol-​3-​yl)​methyl]​-​3-​methyl- | 5-[(7-Chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione | Nec-1s | Necrostatin 2 racemate | Necrostatin 1s

Specifiche e purezza

Moligand™, 10mM in DMSO

Meccanismi biochimici e fisiologici

Necrostatin 2 racemate (Nec-1s, 7-Cl-O-Nec1, Necrostatin-1 stable, Necrostatin 1S) is a stable variant of Necrostatin-1. It is a more specific RIPK1 inhibitor lacking the IDO-targeting effect, with >1000-fold more selective for RIPK1 than for any other

Condizioni di conservazione di stoccaggio

Protected from light,Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

INHIBITOR

Meccanismo d'azione

Inhibitor of receptor interacting serine/threonine kinase 1

Nomi e identificatori

Isomeri SMILES

CN1C(=O)C(NC1=O)CC2=CNC3=C2C=CC=C3Cl

Numero NSC

745841

Peso molecolare

277.7

Reaxy-Rn

10175735

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10175735&ln=

Obiettivi associati (umani)

RIPK1 Tchem Receptor-interacting serine/threonine-protein kinase 1 (1 Activities)

Discover Target: RIPK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Proprietà chimiche e fisiche

• Sensibilità: Light sensitive

Domande frequenti

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C, protected from light. The material is light-sensitive — keep it in its original opaque or amber container.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 852391-15-2, the molecular formula is C13H12ClN3O2, and the molecular weight is 277.7 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.