7-Cl-O-Nec1 - Moligand™, 10mM in DMSO , Inhibitor of receptor interacting serine/threonine kinase 1, CAS No.852391-15-2, Inhibitor of receptor interacting serine/threonine kinase 1

CAS: 852391-15-2 Cat. No.: N409256 Molecular Weight: 277.7

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

7-Cl-O-Nec1, Necrostatin-1 stable, Necrostatin 1S | 2,​4-​Imidazolidinedione, 5-​[(7-​chloro-​1H-​indol-​3-​yl)​methyl]​-​3-​methyl- | 5-[(7-Chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione | Nec-1s | Necrostatin 2 racemate | Necrostatin 1s

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Necrostatin 2 racemate (Nec-1s) Necrostatin 2 racemate (Nec-1s, 7-Cl-O-Nec1, Necrostatin-1 stable, Necrostatin 1S) is a stable variant of Necrostatin-1. It is a more specific RIPK1 inhibitor lacking the IDO-targeting effect, with >1000-fold more selecti
In vitro

Nec-1s is a potent inhibitor of RIPK1 and cellular necroptosis while lacking IDO inhibitory activity.

In vivo

Nec-1s is effective in reducing brain injuries. It is a superior inhibitor suitable for use in vivo lacking a paradoxical sensitizing effect in TNF-induced lethality. Nec-1s possesses several advantageous pharmacokinetic and pharmacodynamic characteristics in comparison to Nec-1. Safety profile of Nec-1s is also superior to that of Nec-1 for reduced in vivo and in vitro toxicity.
Cell Data

cell lines：Cell lines:

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Synonyms

7-Cl-O-Nec1, Necrostatin-1 stable, Necrostatin 1S | 2, ​4-​Imidazolidinedione, 5-​[(7-​chloro-​1H-​indol-​3-​yl)​methyl]​-​3-​methyl- | 5-[(7-Chloro-1H-indol-3-yl)methyl]-3-methyl-2, 4-imidazolidinedione | Nec-1s | Necrostatin 2 racemate | Necrostatin 1s

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Necrostatin 2 racemate (Nec-1s, 7-Cl-O-Nec1, Necrostatin-1 stable, Necrostatin 1S) is a stable variant of Necrostatin-1. It is a more specific RIPK1 inhibitor lacking the IDO-targeting effect, with >1000-fold more selective for RIPK1 than for any other

Storage

Protected from light, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of receptor interacting serine/threonine kinase 1

Names and Identifiers

• Isomeric SMILES: CN1C(=O)C(NC1=O)CC2=CNC3=C2C=CC=C3Cl
• NSC Number: 745841
• Molecular Weight: 277.7
• Reaxy-Rn: 10175735
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10175735&ln=

Associated Targets(Human)

RIPK1 Tchem Receptor-interacting serine/threonine-protein kinase 1 (1 Activities)

Discover Target: RIPK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Sensitivity: Light sensitive