A-485 - Moligand™, 10 mM in DMSO , CAS No.1889279-16-6

CAS: 1889279-16-6 Cat. No.: A1493948 Formula: C₂₅H₂₄F₄N₄O₅ Peso molecolare: 536.48

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

A-485 is a potent and selective catalytic inhibitor of p300/CBP with IC 50 s of 9.8?nM and 2.6?nM for p300 and CBP histone acetyltransferase (HAT), respectively.

Specifications

Specifiche e purezza

Moligand™, 10 mM in DMSO

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

INHIBITOR

Nomi e identificatori

• Isomeri SMILES: C[C@@H](C(F)(F)F)N(CC1=CC=C(C=C1)F)C(=O)CN2C(=O)[C@]3(CCC4=C3C=CC(=C4)NC(=O)NC)OC2=O
• Peso molecolare: 536.48

Riferimenti

1. Junhui Lv, Zhinang Yin, Conghui Li, Honglin Wen, Jian Ni, Peiyuan Yang, Zemin Song, Ying Xiang, Honghong Wang, Rui Lu, Li Huang, Ying Zhou, Hai-Bing Zhou, Ruijing Xiao, Pingping Fang, Kaiwei Liang.  (2025)  KAT6A chimeras form a self-reinforcing epigenetic module with NURF and MLL/COMPASS to sustain AML.  GENOME BIOLOGY,      [PMID:40830799] [10.1186/s13059-025-03743-y]

2. Zongxin Zhu, Ximiao Chen, Hanwen Zhang, Ronghui Miao, Huiling Yu, Shiying Zhao, Youli Zhang, Tanxin Yu, Di Zhang, Yifei Zhou, Xiaolei Zhang, Wei Zhang.  (2026)  Lactate-driven H3K27 lactylation promotes Olig2-dependent remyelination and motor recovery after spinal cord injury.  NEUROPHARMACOLOGY,      [PMID:41525841] [10.1016/j.neuropharm.2026.110832]