ABT-107 - 10mM in DMSO , Neuronal acetylcholine receptor protein alpha-7 subunit agonist, CAS No.855291-54-2, Neuronal acetylcholine receptor protein alpha-7 subunit agonist

CAS: 855291-54-2 Cat. No.: A655699 Formula: C₁₉H₂₀N₄O Peso molecolare: 320.39 PubChem CID: 11151363

QUALITÀ & PUREZZA 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

ABT-107 is a selective α7 neuronal nicotinic receptor agonist. ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions.

In Vivo

ABT-107 exhibits good bioavailability in mouse (orally, 51.1%; intraperitoneally,100%), rat (orally, 81.2%; intraperitoneally, 100.0%), and monkey (orally, 40.6%; intramuscularly,\n100%), and good CNS penetration in rodents with a brain/plasma ratio of 1 . ABT-107 (0.01-1 μmol/kg i.p., 15 min before sacrifice) produces a dose-dependent increase in ERK1/2 and CREB . ABT-107 (0.01, 0.1, and 1.0 mg/kg i.p.) increases S 9 -GSK3 and decreases p-tau in mouse cortex and hippocampus in mice . ABT-107 (5 mg/kg/day i.p.) infusion attenuates tau hyperphosphorylation in AD transgenic APP-tau mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Rats (male Sprague-Dawley; 350-380 g b.wt.) . Dosage: 1, 3 μmol/kg. Administration: I.P. daily for 3 consecutive days. Result: Induced a significant, dose-dependent increase in ACh release by day 3 of repeated administration. Higher doses may be required to evoke ACh release in naive rats not engaged in stimulated, i.e., cognitive-related behavior. Animal Model: Female TAPP (and wild-type littermates) mice . Dosage: 1 mg/kg. Administration: Continuous subcutaneous infusion for 2 weeks. Result: Produced a dose-dependent increase in Ser9 phosphorylation in the cingulate cortex 15 min after acute administration in mice.

Specifiche

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

ABT-107 is a selective α7 neuronal nicotinic receptor agonist. ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions.

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

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Tipo di azione

AGONIST

Meccanismo d'azione

Neuronal acetylcholine receptor protein alpha-7 subunit agonist

Proprietà del prodotto

ALogP

2.6

Nomi e identificatori

Isomeri SMILES

C1CN2CCC1[C@H](C2)OC3=NN=C(C=C3)C4=CC5=C(C=C4)NC=C5

CAS alternativo

855291-54-2

PubChem CID

11151363

Termini MeSH

5-(6-(1-azabicyclo(2,2,2)oct-3-yloxy)pyridazin-3-yl)-1H-indole;ABT 107;ABT-107;ABT107

Peso molecolare

320.39

Obiettivi associati (umani)

CHRNA7 Tchem Neuronal acetylcholine receptor subunit alpha-7 (4 Activities)

Discover Target: CHRNA7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)