ABT-751 (E7010) - ≥98% , Tubulin beta inhibitor, CAS No.141430-65-1, Tubulin beta inhibitor

Name: ABT-751 (E7010) - ≥98% , Tubulin beta inhibitor, CAS No.141430-65-1, Tubulin beta inhibitor
SKU: A125698
Availability: InStock

CAS: 141430-65-1 Cat. No.: A125698 Formula: C₁₈H₁₇N₃O₄S Peso molecolare: 371.41 Numero EC: 689-192-0

COA

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ABT-751 (E7010) - ≥98% CAS No(141430-65-1) by Aladdin Scientific

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Disponibile su ordine

GRADE & PURITY ≥98%

Synonyms

Storage

Store at 2-8°C

Shipped In

Wet ice

Panoramica Specifications Proprietà del prodotto Nomi e identificatori Documentazione Advanced Data Taxonomic Classification Struttura 3D Obiettivi associati (umani) Obiettivi associati (non umani) Meccanismi d'azione Certificati (CoA, COO, BSE/TSE e tabella di analisi) Proprietà chimiche e fisiche Calcolatori di soluzioni Recensioni

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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Panoramica

ABT-751 is an orally bioavailable vascular disrupting agaent (VDA) with a broad spectrum of antitumor activity. It binds to the colchicine binding site on beta-tubulin and inhibits polymerization of microtubules.
An inhibitor of microtubule polymerization

Specifications

Sinonimi

Specifiche e purezza

≥98%

Meccanismi biochimici e fisiologici

ABT-751(E 7010) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively.Antimitotic agent. Microtubule polymerization inhibitor. Induces G

Condizioni di conservazione di stoccaggio

Store at 2-8°C

Spedito in

Wet ice

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

INHIBITOR

Meccanismo d'azione

Tubulin beta inhibitor

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purezza

≥98%

Proprietà del prodotto

ALogP	2.8

Nomi e identificatori

Pubchem Sid	508810304
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/508810304
Sorrisi canonici	COC1=CC=C(C=C1)S(=O)(=O)NC2=C(N=CC=C2)NC3=CC=C(C=C3)O
IUPAC Name	N-[2-(4-hydroxyanilino)pyridin-3-yl]-4-methoxybenzenesulfonamide
InChIKey	URCVCIZFVQDVPM-UHFFFAOYSA-N
INCHI	1S/C18H17N3O4S/c1-25-15-8-10-16(11-9-15)26(23,24)21-17-3-2-12-19-18(17)20-13-4-6-14(22)7-5-13/h2-12,21-22H,1H3,(H,19,20)
Isomeri SMILES	COC1=CC=C(C=C1)S(=O)(=O)NC2=C(N=CC=C2)NC3=CC=C(C=C3)O
CAS alternativo	141430-65-1
Peso molecolare	371.41
Reaxy-Rn	5455834
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5455834&ln=

Documentazione

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Classe Benzene and substituted derivatives
    - Subclass Benzenesulfonamides

Kingdom	Organic compounds
Superclass	Benzenoids
Classe	Benzene and substituted derivatives
Subclass	Benzenesulfonamides
Intermediate Tree Nodes	Not available
Direct Parent	Benzenesulfonamides
Alternative Parents	Benzenesulfonyl compounds p-Aminophenols Phenoxy compounds Methoxybenzenes Anisoles Aniline and substituted anilines 1-hydroxy-2-unsubstituted benzenoids Alkyl aryl ethers Aminopyridines and derivatives Organosulfonamides Imidolactams Heteroaromatic compounds Aminosulfonyl compounds Secondary amines Azacyclic compounds Hydrocarbon derivatives Organic oxides Organopnictogen compounds
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Benzenesulfonamide - Benzenesulfonyl group - Phenoxy compound - P-aminophenol - Aminophenol - Anisole - Phenol ether - Methoxybenzene - Aniline or substituted anilines - Alkyl aryl ether - 1-hydroxy-2-unsubstituted benzenoid - Aminopyridine - Phenol - Pyridine - Imidolactam - Organosulfonic acid amide - Heteroaromatic compound - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Aminosulfonyl compound - Sulfonyl - Organoheterocyclic compound - Azacycle - Ether - Secondary amine - Organic nitrogen compound - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Amine - Organic oxygen compound - Organopnictogen compound - Organic oxide - Aromatic heteromonocyclic compound
Descrizione	This compound belongs to the class of organic compounds known as benzenesulfonamides. These are organic compounds containing a sulfonamide group that is S-linked to a benzene ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Struttura 3D

Obiettivi associati (umani)

ACHN (49357 Activities)

Lot Number	Certificate Type	Data	Oggetto
C1608067	Certificate of Analysis	May 12, 2025	A125698
A1819031	Certificate of Analysis	Jun 08, 2023	A125698

Solubilità	DMSO ≥73mg/mL Water <1.2mg/mL Ethanol ≥13mg/mL
Sensibilità	Heat Sensitive
Punto di fusione (°C)	162 °C(dec.)
Peso molecolare	371.400 g/mol
XLogP3	2.800
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	6
Exact Mass	371.094 Da
Monoisotopic Mass	371.094 Da
Topological Polar Surface Area	109.000 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	523.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1