Ac-DEVD-AMC, CAS No.169332-61-0

CAS: 169332-61-0 Cat. No.: A378562 Molecular Weight: 675.64

GRADE & PURITY ≥97%

Overview

Ac-YEVD-AMCis a fluorogenic substrate for caspase-1 that is a cysteine protease activator of inflammatory processes which may be detected using a varie

Application：

N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin has been used as a substrate for caspase-3 assay in human colon cancer cell line and in bone marrow mesenchymal stem cells.

Specifications

Product Name

Ac-DEVD-AMC, CAS No.169332-61-0

Synonyms

AC-ASP-MET-GLN-ASP-AMC, AC-ASP-MET-GLN-ASP-7-AMINO-4-METHYLCOUMARIN

Specifications & Purity

≥97%

Biochemical and Physiological Mechanisms

Fluorogenic substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase.

Sequence

Ac-Tyr-Glu-Val-Asp-AMC

CAS

169332-61-0

Molecule Type

Peptide

Storage and Shipping

Shape

Solid

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Peptides
          • Level6 Oligopeptides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Peptides
• Direct Parent: Oligopeptides
• Alternative Parents: Glutamic acid and derivatives Aspartic acid and derivatives Valine and derivatives N-acyl-alpha amino acids and derivatives Alpha amino acid amides Coumarins and derivatives 1-benzopyrans Tricarboxylic acids and derivatives N-arylamides Pyranones and derivatives Benzenoids N-acyl amines Heteroaromatic compounds Acetamides Lactones Secondary carboxylic acid amides Carboxylic acids Oxacyclic compounds Carbonyl compounds Hydrocarbon derivatives Organic oxides
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Alpha-oligopeptide - Glutamic acid or derivatives - Aspartic acid or derivatives - Valine or derivatives - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - Coumarin - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - Benzopyran - 1-benzopyran - Tricarboxylic acid or derivatives - N-arylamide - Pyranone - Benzenoid - Fatty acyl - N-acyl-amine - Pyran - Fatty amide - Heteroaromatic compound - Acetamide - Carboxamide group - Lactone - Secondary carboxylic acid amide - Organoheterocyclic compound - Oxacycle - Carboxylic acid - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as oligopeptides. These are organic compounds containing a sequence of between three and ten alpha-amino acids joined by peptide bonds.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y