ACH-000143 - 10mM in DMSO , CAS No.2225836-30-4

CAS: 2225836-30-4 Cat. No.: A656329 Formula: C₁₃H₁₆ClN₃O₃ Peso molecolare: 297.74 PubChem CID: 139451790

GRADE & PURITY 10mM in DMSO

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

ACH-000143 is a potent and orally active melatonin receptor agonist, with EC 50 values of 0.06 nM and 0.32 nM for MT1 and MT2 , respectively

In Vivo

ACH-000143 reduces liver triglycerides and steatosis in diet-Induced obese rats . ACH-000143 is devoid of hERG binding, genotoxicity, and behavioral alterations at doses up to 100 mg/kg p.o., supporting further investigation of this compound as a drug candidate . ACH-000143 significantly reduces plasma glucose at 10 mg/kg (−16.4%, p < 0.05) and 30 mg/kg (−16.9%, p < 0.01) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: High-fat diet rats . Dosage: 10 and 30 mg/kg. Administration: Orally, once daily for two months. Result: Significantly reduced the weekly BW gain on weeks.

IC50& Target:MT1 0.06 nM (EC 50 ) MT2 0.32 nM (EC 50 )

Specifications

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

ACH-000143 is a potent and orally active melatonin receptor agonist, with EC 50 values of 0.06 nM and 0.32 nM for MT1 and MT2 , respectively.

Condizioni di conservazione di stoccaggio

Protected from light,Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

AGONIST

Nomi e identificatori

• Isomeri SMILES: CC(=O)NCCN1C2=CC(=C(C=C2N=C1OC)Cl)OC
• PubChem CID: 139451790
• Peso molecolare: 297.74

Domande frequenti

How should this product be stored?

Store at ?80 °C, protected from light. The material is light-sensitive — keep it in its original opaque or amber container.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2225836-30-4, the molecular formula is C13H16ClN3O3, and the molecular weight is 297.74 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.