AD57 - 10mM in DMSO , CAS No.1093380-42-7

CAS: 1093380-42-7 Cat. No.: A656632 Formula: C₂₂H₂₀F₃N₇O Peso molecolare: 455.44

QUALITÀ & PUREZZA 10mM in DMSO

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Panoramica

AD57 is an orally active multikinase inhibitor, inhibits RET , BRAF , S6K and Src , with greatly reduces mTOR activity

In Vitro

AD57 (0.2 nM) significantly inhibits the ptc > dRet MEN2B lethality in the larva of Drosophila. AD57 (0.1 nM) enhances survival of ptc > dRet MEN2B by reducing erk gene dosage in Drosophila. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AD57 inhibits the viability of MEN2B (MZ-CRC-1) and MEN2A (TT) patient-derived cell lines in RET MEN2 models . AD57 (20 mg/kg) significantly inhibits TT-based tumour growth without obvious cytotoxicity in conventional mouse xenograft model . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Braf

Specifiche

Specifiche e purezza

10mM in DMSO

Meccanismi biochimici e fisiologici

AD57 is an orally active multikinase inhibitor, inhibits RET , BRAF , S6K and Src , with greatly reduces mTOR activity.

Condizioni di conservazione di stoccaggio

Protected from light,Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

INHIBITOR

Nomi e identificatori

Peso molecolare

455.44