Ajmaline - 10mM in DMSO , CAS No.4360-12-7

CAS: 4360-12-7 Cat. No.: A423961 Formula: C₂₀H₂₆N₂O₂ Peso molecolare: 326.43 Numero EC: 224-439-4

GRADE & PURITY 10mM in DMSO

Synonyms

(+)-Ajmaline|4360-12-7|Ajmalan-17,21-diol, (17R,21a)-|Ajmalin|Ajmaline|Cardiorythmine|Gilurytmal|Ignazin|Merabitol|NSC 15627|Raugalline|Rauwolfin|Rauwolfine|Rhytmaton|Ritmos|Rytmalin|Siddiqui|Tachmalin|Takycor|Ajmaline [JAN]|1PON08459R|Ajmalan-17,21-diol|

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Specifications

Sinonimi

(+)-Ajmaline | 4360-12-7 | Ajmalan-17,21-diol, (17R,21a)- | Ajmalin | Ajmaline | Cardiorythmine | Gilurytmal | Ignazin | Merabitol | NSC 15627 | Raugalline | Rauwolfin | Rauwolfine | Rhytmaton | Ritmos | Rytmalin | Siddiqui | Tachmalin | Takycor | Ajmaline [JAN] | 1PON08459R | Ajmalan-17,21-diol |

Specifiche e purezza

10mM in DMSO

Condizioni di conservazione di stoccaggio

Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Nomi e identificatori

• Pubchem Sid: 528776286
• Sorrisi canonici: CCC1C2CC3C4C5(CC(C2C5O)N3C1O)C6=CC=CC=C6N4C
• IUPAC Name: (1R,9R,10S,12R,13S,14R,16S,17S,18R)-13-ethyl-8-methyl-8,15-diazahexacyclo[14.2.1.01,9.02,7.010,15.012,17]nonadeca-2,4,6-triene-14,18-diol
• InChIKey: CJDRUOGAGYHKKD-RQBLFBSQSA-N
• INCHI: 1S/C20H26N2O2/c1-3-10-11-8-14-17-20(12-6-4-5-7-13(12)21(17)2)9-15(16(11)18(20)23)22(14)19(10)24/h4-7,10-11,14-19,23-24H,3,8-9H2,1-2H3/t10-,11-,14-,15-,16-,17-,18+,19+,20+/m0/s1
• Isomeri SMILES: CC[C@H]1[C@@H]2C[C@H]3[C@H]4[C@@]5(C[C@@H]([C@H]2[C@H]5O)N3[C@@H]1O)C6=CC=CC=C6N4C
• Peso molecolare: 326.43
• Reaxy-Rn: 568202
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=568202&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Alkaloids and derivatives
    • Classe Ajmaline-sarpagine alkaloids

• Kingdom: Organic compounds
• Superclass: Alkaloids and derivatives
• Classe: Ajmaline-sarpagine alkaloids
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Ajmaline-sarpagine alkaloids
• Alternative Parents: Beta carbolines Quinolizidines Quinuclidines Dialkylarylamines Azepanes Aralkylamines Piperidines Benzenoids Secondary alcohols Hemiaminals Cyclic alcohols and derivatives Azacyclic compounds Organopnictogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Sarpagine-skeleton - Beta-carboline - Pyridoindole - Quinolizidine - Indole or derivatives - Dialkylarylamine - Quinuclidine - Tertiary aliphatic/aromatic amine - Azepane - Aralkylamine - Benzenoid - Piperidine - Cyclic alcohol - Secondary alcohol - Tertiary amine - Hemiaminal - Organoheterocyclic compound - Azacycle - Alkanolamine - Alcohol - Organopnictogen compound - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Amine - Organooxygen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• Descrizione: This compound belongs to the class of organic compounds known as ajmaline-sarpagine alkaloids. These are organic compounds containing either of the ajmalan, sarpagan skeleton, or derivative thereof. The Sarpagine (Akuammidine) group, based on the sarpagan nucleus, arises from bond formation between C-16 and C-5 of the corynantheine precursor. Ajmaline alkaloids are based on a 17,19-secoyohimban skeleton (oxayohimban) which is invariably present as an ether.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Proprietà chimiche e fisiche

• Peso molecolare: 326.400 g/mol
• XLogP3: 1.800
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 326.199 Da
• Monoisotopic Mass: 326.199 Da
• Topological Polar Surface Area: 46.900 Ų
• Heavy Atom Count: 24
• Formal Charge: 0
• Complexity: 570.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 9
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Riferimenti

1. Min Chen, Wenhuan Chen, Xinyi Jiang, Shaomei Liang, Yingqiao Qin, Jiayi Tang, Yifei Li, Qifan Wu, Xue Liang, Pengcheng Wei, Kunpeng Liu, Sulan Luo.  (2026)  Virtual screening targeting the conserved domain of the IAV M2 protein reveals the potential broad-spectrum anti-IAV activity of ajmaline.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,      [PMID:41881854] [10.1016/j.bbrc.2026.153643]