Amcasertib (BBI503) - Moligand™, ≥95% , CAS No.1129403-56-0

CAS: 1129403-56-0 Cat. No.: A414065 Formula: C₃₁H₃₃N₅O₂S Peso molecolare: 539.69

GRADE & PURITY Moligand™, ≥95%

Synonyms

1H-Pyrrole-3-carboxamide | N-​[2-​(diethylamino)​ethyl]​-​5-​[[1,​2-​dihydro-​2-​oxo-​5-​(2-​phenyl-​4-​thiazolyl)​-​3H-​indol-​3-​ylidene]​methyl]​-​2,​4-​dimethyl-

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Panoramica

Information

Amcasertib (BBI503) Amcasertib (BBI503), a first-in-class cancer stemness kinase inhibitor, is claimed to inhibit Nanog and other CSC pathways by targeting kinases with potential anticancer activity.

Targets

Nanog

In vitro

BBI-503 is orally-administered compound, which is designed to target CSC pathways in multiple tumour types.

In vivo

BBI503 inhibits Nanog and other cancer stem cell pathways by targeting kinases, and shows encouraging early signs of anti-cancer activity for patients with advanced colorectal cancer.

Specifications

Sinonimi

1H-Pyrrole-3-carboxamide | N-​[2-​(diethylamino)​ethyl]​-​5-​[[1,​2-​dihydro-​2-​oxo-​5-​(2-​phenyl-​4-​thiazolyl)​-​3H-​indol-​3-​ylidene]​methyl]​-​2,​4-​dimethyl-

Specifiche e purezza

Moligand™, ≥95%

Meccanismi biochimici e fisiologici

Amcasertib (BBI503), a first-in-class cancer stemness kinase inhibitor, is claimed to inhibit Nanog and other CSC pathways by targeting kinases with potential anticancer activity.

Condizioni di conservazione di stoccaggio

Store at -20°C

Spedito in

Ice chest + Ice pads

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Grado

Moligand™

Tipo di azione

INHIBITOR

Purezza

≥95%

Proprietà del prodotto

• ALogP: 5.119
• hba_count: 3
• Conteggio HBD: 3
• Legame rotabile: 9

Nomi e identificatori

• Pubchem Sid: 504772359
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504772359
• Sorrisi canonici: CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)C4=CSC(=N4)C5=CC=CC=C5)NC2=O)C
• IUPAC Name: N-[2-(diethylamino)ethyl]-2,4-dimethyl-5-[[2-oxo-5-(2-phenyl-1,3-thiazol-4-yl)-1H-indol-3-ylidene]methyl]-1H-pyrrole-3-carboxamide
• InChIKey: QDWKGEFGLQMDAM-UHFFFAOYSA-N
• INCHI: 1S/C31H33N5O2S/c1-5-36(6-2)15-14-32-30(38)28-19(3)26(33-20(28)4)17-24-23-16-22(12-13-25(23)34-29(24)37)27-18-39-31(35-27)21-10-8-7-9-11-21/h7-13,16-18,33H,5-6,14-15H2,1-4H3,(H,32,38)(H,34,37)
• Isomeri SMILES: CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)C4=CSC(=N4)C5=CC=CC=C5)NC2=O)C
• Peso molecolare: 539.69
• Reaxy-Rn: 18996620
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=18996620&ln=

Proprietà chimiche e fisiche

• Solubilità: Solubility (25°C) In vitro DMSO: 14 mg/mL (25.94 mM); Ethanol: 1 mg/mL (1.85 mM); Water: Insoluble
• DMSO (mg/mL) Solubilità massima: 14
• DMSO (mM) Solubilità massima: 25.94081788
• Acqua (mg/mL) Solubilità massima: ＜1