AMG PERK 44 - ≥95% , CAS No.1883548-84-2

CAS: 1883548-84-2 Cat. No.: A286749 Formula: C34H28N4O2•HCl Peso molecolare: 561.07
Disponibile su ordine
GRADE & PURITY ≥95%
Synonyms
4-[2-Amino-4-methyl-3-(2-methyl-6-quinolinyl)benzoyl]-1,2-dihydro-1-methyl-2,5-diphenyl-3H-pyrazol-3-one hydrochloride
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
★
Size
Germania (EU)
USA*
Price
Qty
1mg
A286749-1mg
—
3 Disponibile
86,69€
5mg
A286749-5mg
—
3 Disponibile
260,23€
10mg
A286749-10mg
—
2 Disponibile
416,43€
25mg
A286749-25mg
—
2 Disponibile
832,94€
50mg
A286749-50mg
—
1 Disponibile
1.388,30€
Enter a quantity for the sizes you want to add.
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Why this grade

≥95% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Panoramica

AMG PERK 44 is an orally effective, highly selective PERK inhibitor with an IC50 of 6 nM. The selectivity of AMG PERK 44 for PERK is 1000 and 160 times higher than that of GCN2 (IC50=7300 nM) and B-Raf (IC50>1000 nM), respectively. AMG PERK 44 can induce autophagy.

Specifications

Sinonimi
4-[2-Amino-4-methyl-3-(2-methyl-6-quinolinyl)benzoyl]-1,2-dihydro-1-methyl-2,5-diphenyl-3H-pyrazol-3-one hydrochloride
Specifiche e purezza
≥95%
Meccanismi biochimici e fisiologici
Potent and selective PERK inhibitor (IC50= 6 nM). Exhibits >160-fold selectivity for PERK over B-Raf and GCN2, as well as a panel of 387 other kinases. Orally bioavailable.
Condizioni di conservazione di stoccaggio
Store at -20°C
Spedito in
Ice chest + Ice pads
Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.
Tipo di azione
INHIBITOR
Purezza
≥95%
Nomi e identificatori
Pubchem Sid528763095
Sorrisi canoniciCC1=C(C(=C(C=C1)C(=O)C2=C(N(N(C2=O)C3=CC=CC=C3)C)C4=CC=CC=C4)N)C5=CC6=C(C=C5)N=C(C=C6)C.Cl
IUPAC Name4-[2-amino-4-methyl-3-(2-methylquinolin-6-yl)benzoyl]-1-methyl-2,5-diphenylpyrazol-3-one;hydrochloride
InChIKeyRNAKBTDDCHJCMT-UHFFFAOYSA-N
INCHI1S/C34H28N4O2.ClH/c1-21-14-18-27(31(35)29(21)25-17-19-28-24(20-25)16-15-22(2)36-28)33(39)30-32(23-10-6-4-7-11-23)37(3)38(34(30)40)26-12-8-5-9-13-26;/h4-20H,35H2,1-3H3;1H
Peso molecolare 561.07
Reaxy-Rn 27969561
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=27969561&ln=

Documentazione

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Struttura 3D
Modello di struttura chimica interattiva





Certificati (CoA, COO, BSE/TSE e tabella di analisi)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot NumberCertificate TypeDataOggetto
H2429044Certificate of AnalysisMay 22, 2024 A286749
H2429045Certificate of AnalysisMay 22, 2024 A286749
H2429046Certificate of AnalysisMay 22, 2024 A286749
H2429047Certificate of AnalysisMay 22, 2024 A286749
H2429048Certificate of AnalysisMay 22, 2024 A286749
H2429049Certificate of AnalysisMay 22, 2024 A286749
H2429050Certificate of AnalysisMay 22, 2024 A286749
H2429051Certificate of AnalysisMay 22, 2024 A286749
H2429052Certificate of AnalysisMay 22, 2024 A286749
H2429179Certificate of AnalysisMay 22, 2024 A286749
Proprietà chimiche e fisiche
SolubilitàSolvent:DMSO, Max Conc. mg/mL: 11.22, Max Conc. mM: 20
SensibilitàMoisture sensitive
Domande frequenti e articoli
Calcolatori di soluzioni
Recensioni

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